Investigators from Cerevance Inc. have reported the discovery and preclinical characterization of a novel tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) inhibitor, C-101248, being developed for the treatment of neuroinflammation in Alzheimer’s disease (AD). NETSseq and histological analysis revealed that THIK-1 expression was up-regulated in microglia from different cortical regions of AD donors compared with aged matched nondemented control brains.
Researchers led by Doron Merkler from the University of Geneva have shown how post local infection, a fraction of resting CD8+ tissue resident memory cells cross-reacted with antigens of the CNS to become subsequently activated and drive immunopathological responses in the CNS.
Immunologists at Sun Yat-sen University in Guangzhou, China, have been the first to show that interferon-induced protein 35 family proteins promote neuroinflammation and multiple sclerosis (MS), as they reported in the August 2, 2021, edition of Proceedings of the National Academy of Sciences.
Investigators at the Tokyo Metropolitan Institute of Medical Science have identified the oxidative stress sensor DJ-1 as a previously unknown inflammatory molecule which is released from damaged neurons to activate macrophages in post-stroke neuroinflammation.
Chinese neuroscientists have identified a bone marrow (BM) response to acute brain injury, in which the fate and function of BM hematopoietic cells are shaped by brain injury, suggesting that the brain can mobilize a population of protective monocytes and direct them to the injury site.
