Chimeric antigen receptor (CAR) T cells are astounding. In B-cell cancers, they have been transformative. Yet engineering-wise, CAR T cells are in the equivalent of the Model T era. CAR T-cell engineering has already evolved, with the addition of costimulatory domains, which affect cell expansion and signaling. But once the cells are injected into a patient, there is really no way to affect their behavior.
As many as 3.8 million people experience a traumatic brain injury (TBI) each year in the United States and it is also the strongest environmental risk factor for developing dementia, but there are no treatments to mitigate deficits from TBI.
The changes continue at GSK plc as the pharma giant stepped away from its NY-ESO cell therapy program in moves that touch two collaborators. The company is terminating its three-year partnership with Lyell Immunopharma Inc. to develop candidates targeting NY-ESO-1, including the second‑generation product candidates, Lyell’s genetic and epigenetic reprogramming technologies (LYL-132 and LYL-331), and some other second-generation approaches GSK was considering.
With the science on aging advancing, it’s time for the U.S. to modernize its regulatory approval path for new longevity treatments, members of a House Science, Space and Technology subcommittee were told Sept. 15.
With an ambitious promise to unravel the biology of cellular rejuvenation programming, Altos Labs Inc. launched Jan. 19 with $3 billion in committed funding and an impressive roster of academic and industry leaders.
