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BioWorld - Friday, July 18, 2025
Home » Topics » Science, BioWorld MedTech

Science, BioWorld MedTech
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Carotid ultrasound
Aging

UK Biobank project complete, supports research with 100,000 scans

July 17, 2025
By Nuala Moran
No Comments
After a 10-year project and a £60 million (US$80 million) investment, the UK Biobank has completed the whole body scans of 100,000 volunteers and is making the 1 billion images available for researchers worldwide.
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Brain and neural networks
Biomarkers

Proteomics finds surprise commonalities as well as differences in neurodegenerative diseases

July 15, 2025
By Nuala Moran
No Comments
The switch will be flicked today to make the world’s largest dementia-related proteomics dataset freely available to researchers, at the same time as members of the consortium which compiled it publish the proteomics signatures of major neurodegenerative diseases that they uncovered in a first trawl of the data.
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Rare disease illustration

UK industry encourages renewal of rare disease framework

July 8, 2025
By Nuala Moran
No Comments
Representatives of patients’ groups, industry bodies and venture philanthropy funders are calling for a renewal of the U.K. Rare Diseases Framework, to put fresh momentum behind translational research and clinical trials, streamline regulatory oversight and improve access to therapies.
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Multiple sclerosis
Neurology/psychiatric

At EAN 2025, DEI Hub launches to improve care for all

June 26, 2025
By Anette Breindl
No Comments
In recognition of the fact that diversity, equity and inclusion are necessary prerequisites for precision medicine, the European Academy of Neurology announced the launch of a DEI Hub at its 11th Congress, which is being held in Helsinki through June 24.
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3D rendering of CAR T therapy in cell
Neurology/psychiatric

EAN 2025: CAR T cells take on neurological disorders

June 25, 2025
By Anette Breindl
No Comments
At the 11th Congress of the European Academy of Neurology, which was held in Helsinki June 21 to June 24, researchers presented new data on using CAR T cells in autoimmune neurological conditions.
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3D illustration of a chain of amino acid or biomolecules called protein

Alphadesign: AI creating proteins from scratch

June 17, 2025
By Nuala Moran
No Comments
The Alphafold machine learning system for predicting a protein’s structure from its amino acid sequence has been adapted to make it possible to design de novo proteins that fold in a particular way and bind to prespecified target proteins. The sister system, called Alphadesign, works by generating random strings of amino acids, using Alphafold to predict their structure, and then iteratively optimizing the design.
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Liver
Gastrointestinal

Precision medicine approach identifies culprit in alcohol-associated hepatitis

May 29, 2025
By Anette Breindl
No Comments
Researchers have identified KpsM as a virulence factor in Escherichia coli that was responsible for liver damage in alcohol-associated hepatitis (AH). A small-molecule inhibitor of KpsM reduced liver damage in animal models of AH.
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Liver illustration
Endocrine/metabolic

Liver is also immune organ, influenced by microbiome

May 14, 2025
By Anette Breindl
No Comments
Immunity is not a function most people particularly associate with the liver. But because of its connection to the gut, the liver is exposed to bacterial metabolites as few other organs are. And when either the liver or the gut is not functioning well, it can adversely affect immunity as well.
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Harvard University Widener Library

Harvard fighting back with lawsuit against Trump administration

April 23, 2025
By Nuala Moran
Harvard University has filed a lawsuit claiming the Trump administration’s freezing of its federal funding is unlawful and beyond the government’s authority. Announcing the move, Harvard’s president, Alan Garber, highlighted the impact of freezing $2.2 billion in grants – and the threat to freeze a further $1.1 billion – will have on the university’s biomedical research.
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Illustration of human brain and dna
Neurology/psychiatric

Commander proteins linked to lysosomal dysfunction in Parkinson’s

April 22, 2025
By Mar de Miguel
Genes associated with lysosomal dysfunction increase the risk of Parkinson’s disease (PD), according to a study led by scientists at Northwestern University. The discovery also explains why some people who carry a pathogenic variant of the GBA1 gene develop PD or dementia with Lewy bodies (DLB) and others do not. The key lies in the Commander complex, involved in the transport of proteins to this organelle. This discovery raises the need for combinatorial therapies that act on more than one pathway for this type of neurodegenerative disorder.
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