Lowering levels of tau protein improved multiple symptoms of autism spectrum disorders (ASD) in two different mouse models of the disease, both of which are driven by hyperactivity of the mTOR PI3 kinase pathway.
Keeping you up to date on recent developments in oncology, including: Study identifies two different cancer stem cells in cervical cancer; How cancer cells hibernate…; …And who makes their bed; Blocking trash trashes MSI-hi tumors.
Sadly, a major part of the answer to why drugs are so expensive appears to be “because they can be.” But the high cost of drugs has also spurred a number of attempts to find medicines that are innovative but remain affordable. Drug repurposing, or using a drug that has been developed for one ailment to treat a different one, is one such strategy.
Keeping you up to date on recent developments in cardiology, including: MRI yields insights into blood flow of men, women; AHA: Take it slow and study with exercise; Intensive blood pressure control seen as extending life up to 3 years.
Lowering levels of tau protein improved multiple symptoms of autism spectrum disorders (ASD) in two different mouse models of the disease, both of which are driven by hyperactivity of the mTOR PI3 kinase pathway.
BioWorld looks at translational medicine, including: Finding the next pandemic threat early on; Microglial fresh start helps heal brain trauma; Finding the silent majority; Anatomy study reveals schizophrenia subtypes; Increasing immune activity improves autoimmunity; How cancer cells hibernate…; …And who makes their bed; Blocking trash trashes MSI-hi tumors; New splicing factor implicated in muscular dystrophy.
Keeping you up to date on recent developments in neurology, including: Multisensor band developed to record subtle changes in patients with MS; Study finds surveillance after glioblastoma surgery does not improve outcomes; New CRISPR base-editing technology slows ALS progression in mice; Resetting immune cells improves TBI recovery in mice.
Beyond every binary is a more complex reality. And so it is with driver and passenger mutations. The separation of tumor mutations into drivers and passengers underpins much progress in the development of targeted therapies.
Keeping you up to date on recent developments in diagnostics, including: Chest CT bests assays in diagnosing Covid-19; Sweat sensor keeps tabs on stress; Oligodendrocyte-neural connections not just about myelin; Sharper look yields new potential kinase target in ovarian cancer.
Everything’s good for something. Including, it turns out, 5’ untranslated trinucleotide repeats. In the Feb. 17, 2020, issue of Nature Neuroscience, researchers have demonstrated a role for such repeats in controlling protein levels of fragile X mental retardation protein (FMRP).
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