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BioWorld - Thursday, May 19, 2022
Home » Topics » Science

Science
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Patient-derived antibody activates innate immune system

May 18, 2022
By Anette Breindl
No Comments
A target-agnostic search has yielded a patient-derived antibody that activated the innate immune system, researchers from Atreca and Stanford University reported in the May 4,2022, issue of the Proceedings of the National Academy of Sciences.
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Aging illustration

Multiple aging hallmarks show up as epigenetic changes

May 16, 2022
By Anette Breindl
No Comments
Age is the biggest risk factor for just about every common disease in high-income countries, which suggests that slowing down cellular aging would have massive effects on individual and public health. Delaying the average onset of Alzheimer’s disease by five years, for example, would roughly halve its prevalence. But in practice, there are no approved anti-aging medications.
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Cancer cell and DNA

Diabetic foot ulcers hold clues to tumor suppression

May 16, 2022
By W. Todd Penberthy
No Comments
New genomic research has increased the understanding of surprising links between diabetic foot ulcers and carcinomas.
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Assembling a draft Human Cell Atlas

Across body parts, ‘parts list’ gives insights into the lives of a cell

May 12, 2022
By Anette Breindl
No Comments
“People often think about the genome as the blueprint of the organism, but that’s not really correct,” Steven Quake told reporters at a Science press briefing earlier this week. “The genome is more of a parts list, because every cell type uses different parts.” Quake is president of the Chan Zuckerberg Biohub Network, and professor of bioengineering and applied physics at Stanford University.
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Back pain

Inflammation is key to preventing chronic pain, study finds

May 11, 2022
By Anette Breindl
No Comments
More than 10% of Americans suffer from chronic pain, and how to prevent acute pain from turning chronic has been a critical question in pain research. But according to a study published in the May 11, 2022, issue of Science Translational Medicine, that approach has it backwards. In several animal models of pain, the resolution of acute pain was an active process. Chronic pain happened when those active processes failed to occur.
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Glucose testing

Type 2 diabetes getting precision medicine makeover

May 11, 2022
By Nuala Moran
No Comments
Type 2 diabetes is known to involve many different underlying mechanisms, but the considerable heterogeneity in the phenotype is mostly ignored in how it is treated. Now, researchers at University of Dundee, U.K., have developed a method for visualizing this heterogeneity and shown how the risks of complications, such as chronic kidney disease or peripheral neuropathy, differ by phenotypes.
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Breast cancer illustration
ESMO Breast Cancer 2022

Taking aim at tumor metabolism, while taming toxicity

May 10, 2022
By Anette Breindl
No Comments
There are 40 years of history behind the development of phosphoinositide 3-kinase (PI3K) inhibitors, Rebecca Dent told her audience at ESMO Breast Cancer 2022. And there have been success stories. There are five FDA-approved PI3K inhibitors in several cancer types, and in April, the FDA approved Vijoice (alpelisib; Novartis AG) for PIK3CA-related overgrowth spectrum, a rare disorder resulting from germline mutations of PIK3CA.
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Fallopian tubes, ovaries and uterus

Comparative study focuses lens of human reproductive aging

May 10, 2022
By Anette Breindl
No Comments
A comparison of seven nonhuman primate species has found both similarities and differences among the effects of age on female reproduction.
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Silhouette made of crumpled paper illustrating depression

Proline links gut microbiome to depression

May 9, 2022
By Nuala Moran
No Comments
If it is now acknowledged the gut microbiota plays a role in the pathophysiology of depression, the specific biochemical mechanisms underlying this connection are hard to unpick and poorly understood.
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Breast cancer illustration
ESMO Breast Cancer 2022

Taking aim at tumor metabolism, while taming toxicity

May 6, 2022
By Anette Breindl
No Comments
There are 40 years of history behind the development of phosphoinositide 3-kinase (PI3K) inhibitors, Rebecca Dent told her audience at ESMO Breast Cancer 2022. And there have been success stories. There are five FDA-approved PI3K inhibitors in several cancer types, and in April, the FDA approved Vijoice (alpelisib; Novartis AG) for PIK3CA-related overgrowth spectrum, a rare disorder resulting from germline mutations of PIK3CA.
Read More
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