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BioWorld - Tuesday, June 17, 2025
Home » Topics » Science

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Valo raises €19M for immunotherapy work

March 11, 2025
By Nuala Moran
Finnish cancer immunotherapy specialist Valo Therapeutics Oy has raised €19 million (US$20.7 million) in a round that attracted Italian and Australian investors, and funding the company to the completion of the ongoing phase Ib trial of its lead program in the treatment of solid tumors.
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HIV infected cell
HIV/AIDS

At CROI, HIV cure trials raise hopes for broader applicability

March 11, 2025
By Anette Breindl
At the 2025 meeting of the Conference on Retroviruses and Opportunistic Infections (CROI) it was the best of times, it was the worst of times. On the first full day of the conference, reports from the first HIV cure trial conducted in Africa, the RIO trial and others showed that perhaps, a broadly useful cure is on the horizon.
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HIV infected cell
HIV/AIDS

At CROI, HIV cure trials raise hopes for broader applicability

March 11, 2025
By Anette Breindl
At the 2025 meeting of the Conference on Retroviruses and Opportunistic Infections (CROI) it was the best of times, it was the worst of times. On the first full day of the conference, reports from the first HIV cure trial conducted in Africa, the RIO trial and others showed that perhaps, a broadly useful cure is on the horizon.
Read More
Stethoscope, hand, health care icons

CDC briefing: Trump cuts disrupt disease surveillance, deplete talent

March 10, 2025
By Nuala Moran
Three public health experts have voiced concerns that the uncertainties sparked by the Trump administration’s moves to reduce federal spending could limit the U.S. CDC’s ability to track and respond to infectious disease outbreaks and will undermine the public health support system in the U.S.
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Microbiome illustration
Infection

Synthetic microbiome prevents Clostridioides difficile recurrences

March 7, 2025
By Coia Dulsat
Investigators at Pennsylvania State University have described a novel approach to combat Clostridioides difficile infection using a synthetic microbiome therapy, which offers an alternative to antibiotics and fecal microbiota transplant .
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Genome concept art.

Study looks to noncoding gene variants for new drug targets

March 6, 2025
By Nuala Moran
A new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on gene expression levels and gene splicing, the post-transcriptional modification that allows one gene to code for multiple proteins.
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Microbiome illustration
Infection

Synthetic microbiome prevents Clostridioides difficile recurrences

March 6, 2025
By Coia Dulsat
Investigators at Pennsylvania State University have described a novel approach to combat Clostridioides difficile infection using a synthetic microbiome therapy, which offers an alternative to antibiotics and fecal microbiota transplant (FMT). C. diff, the main cause of antibiotic-related diarrhea, is responsible for an estimated half a million infections annually in the U.S.
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3D illustration of melanoma
Cancer

Combination therapy overcomes treatment resistance in melanoma

March 4, 2025
By Mar de Miguel
Researchers at the University of California San Diego have uncovered a key mechanism underlying the treatment resistance of melanoma with the BRAF V600E mutation through pathways involved in focal adhesion and extracellular matrix (ECM) remodeling. These two processes remodel the tumor cell environment in melanoma through the RAF/MEK cell signaling pathway. However, the combined use of FAK inhibitors with a RAF-MEK clamp overcame this resistance.
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AI-generated depiction of lungs affected by cystic fibrosis
Respiratory

‘Remarkable’ progress in cystic fibrosis means more work needed

Feb. 28, 2025
By Nuala Moran
The map of cystic fibrosis (CF) research is being redrawn in the U.K. as improvements in treatment, and in particular the introduction of CF modulator drugs, mean people with the rare inherited disease are living much longer.
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Mitochondria
Genetic/congenital

For therapeutic hypoxia, small molecule can mimic mountain trip

Feb. 28, 2025
By Anette Breindl
Too much of a good thing, it turns out, is a concept that applies to oxygen. And researchers at the University of California at San Francisco are working on a small molecule, Hypoxystat, that can lower tissue oxygen levels and prevent damage when oxygen levels are too high. When administered to mice with the rare mitochondrial disorder Leigh syndrome, the molecule more than tripled their average lifespan.
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