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BioWorld - Sunday, August 14, 2022
Home » Topics » Science

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Sickle cell disease

Limitations of certain mouse models for sickle cell research highlighted

July 8, 2022
By Helen Albert
No Comments
Research carried out by a team at St. Jude Children's Research Hospital in Memphis highlights the importance of carefully assessing the mouse model you plan to use before starting preclinical medical research.
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Cancer cell, DNA illustration

BRCA1 methylation, mutation portend different response to chemotherapy

July 7, 2022
By Anette Breindl
No Comments
No matter how they come about, functional impairments in the DNA repair protein BRCA1 will hamper cells' ability to repair their genome, and increase the chances that a cell will become cancerous. However, researchers from the Jackson Laboratory for Genomic Medicine reported in the July 6, 2022, issue of Science Translational Medicine that reduced BRCA1 activity that was due to methylation of its promoter differed from BRCA1 mutation in terms of its response to platinum chemotherapy.
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Cross section of brain

Postmortem brain study gives clues to long COVID

July 6, 2022
By Anette Breindl
No Comments
SARS-CoV-2 infection caused damage to brain blood vessels via a cascade of immune system reactions that was most likely initiated by antibody-dependent cytotoxicity, researchers from the National Institute of Neurological Disorders and Stroke reported in the July 5, 2022, online issue of Brain.
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RNA

RNA-binding protein helps colon cancer cells persist

July 5, 2022
By Anette Breindl
No Comments
Researchers have identified an RNA-binding protein that played a role in colon cancer relapse, offering new insights into how cells persist in the presence of chemotherapy.
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Researchers in lab demonstrating technology

New monitor may help surgeons detect blood clots faster

July 1, 2022
By David Godkin
No Comments
The University of Central Florida (UCF) and Orlando Health are testing new medical technology designed to identify blood clots more quickly in surgery. The monitoring device consists of a small optical fiber that uses red blood cells to track the process of blood coagulation in patients so doctors can watch for life threatening blood clot formation.
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Cancer cells under magnifying glass

Tumors might be nudged to more treatable state

July 1, 2022
By Anette Breindl
No Comments
Researchers at the Institute for Cancer Research have demonstrated that in pancreatic tumors, the balance between a more aggressive mesenchymal and a less aggressive epithelial state is constantly in flux, depending on an interplay of different regulatory proteins.
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Person in wheelchair

CSF1R inhibition could delay muscular dystrophy progression

July 1, 2022
By W. Todd Penberthy
No Comments
Investigators at University of British Columbia have reported the precise cellular populations responsible for the inability to regenerate muscle tissues in muscular dystrophy.
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Amyloid plaques forming between neurons

Myelin-forming cells change in multiple brain diseases

June 29, 2022
By Anette Breindl
No Comments
Investigators at the Weizmann Institute of Science have identified changes in oligodendrocytes that were shared across multiple dementia types. The team reported its results in the June 27, 2022, online issue of Nature Neuroscience.
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Tract mapping in the human brain
EAN 2022

At several scales, connective landscape provides lens for neurology

June 28, 2022
By Anette Breindl
No Comments
Connections, Susan Greenfield told her audience at the 2022 Annual Conference of the European Academy of Neurology, are what the mind is all about. "When you are born, you are born with a fair amount of neurons," she said at the conference's opening plenary on Sunday. But "what characterizes the growth of the brain postnatally is the configurations of connections."
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Liver illustration

Molecular signature predicts cancer risk in patients with NAFLD

June 27, 2022
By Helen Albert
No Comments
Research led by the University of Texas Southwestern Medical Center reveals a protein signature that can reliably predict whether patients with nonalcoholic fatty liver disease (NAFLD) are likely to develop hepatocellular carcinoma, the most common form of liver cancer.
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