“In 2015, when I started in this field…. people considered breast cancer a cold tumor,” Marleen Kok told the audience at the European Society of Medical Oncology’s 2022 Targeted Anticancer Therapy meeting (ESMO TAT). But the sensitivity of breast cancer to immunotherapy, or lack thereof, is “not a black and white phenomenon.”

An international collaboration led by scientists at The University of South Australia, SA Pathology in Adelaide, and the de Duve Institute, University of Louvain, Belgium, has discovered biallelic MDFIC pathogenic variants underlying the severe lymphatic disorder, central conducting lymphatic anomaly (CCLA), in seven people from six separate families.

By using engineered retinal pigment epithelial cells to deliver IL-2 into the tumor microenvironment, investigators at Rice University eradicated ovarian and colorectal tumors in mouse models, and elicited T-cell responses after implantation in primates.

Researchers from Massachusetts General Hospital have identified peripheral neuropathy in more than half of a group of long COVID patients, suggesting that it may be a mechanism that contributes to multiple, seemingly disparate, long COVID symptoms.

A Chinese study led by researchers at Fudan University in Shanghai has described a novel strategy to target the "undruggable" mutant Huntingtin protein by screening for compounds that directly bind to the 'undruggable' target and rescue disease-relevant phenotypes.

Scientists at Osaka University have discovered that intercellular communication via extracellular vesicles from osteoblasts, cells that are specialized for laying down new bone, is a key factor for the transition from bone formation to resorption via a microRNA (miRNA)-mediated mechanism.

A study from the Max Planck Institute for Evolutionary Anthropology and the Karolinska Institute has shown that individuals who carry the major genetic risk variant for severe COVID-19 infection are less likely to contract HIV.

Antibiotic treatment that changed the lung microbiome affected the activity of microglia, the brain-specific version of macrophages, and could prevent the development of the multiple sclerosis model experimental autoimmune encephalitis in mice.

Timothy syndrome, a rare autosomal-dominant disorder, is characterized by presence of a heart arrhythmia (long QT syndrome), which causes the cardiac muscle to take longer than usual to recharge between beats and can result in sudden death. Now scientists at Columbia University have discovered that a common FDA-approved over-the counter cough suppressant, dextromethorphan, can shorten the prolonged QT intervals in both cellular and mouse models of TS.