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Amish man and horses

Newly identified variant has large effects on two aspects of cardiovascular risk

Dec. 6, 2021
By Anette Breindl
In the Dec. 3, 2021, issue of Science, researchers reported that a missense variant that is highly enriched in the Amish population was associated with reduced levels of both LDL cholesterol and fibrinogen. To date, very few variants have been identified that affect more than one risk factor for cardiovascular disease.
Read More
Brain with puzzle piece removed
ED to AD

Viagra, cataract surgery associated with lower risk of Alzheimer’s disease

Dec. 6, 2021
By Anette Breindl
Far from the Groundhog Day spectacle of amyloid-targeting antibodies that do little to nothing for patients in trial after trial, researchers have reported success in reducing the risk of Alzheimer’s disease (AD) in unexpected ways. Researchers at the Cleveland Clinic Foundation have discovered that a Viagra prescription was associated with a roughly 70% reduced risk of being diagnosed with AD. And investigators from the University of Washington reported that in the prospective Adult Changes in Thought study, a long-term study into risk and protective factors for dementia, persons who underwent cataract surgery reduced their risk of AD by 30%, an effect that lasted for 10 years after surgery.
Read More
Amish man and horses

Newly identified variant has large effects on two aspects of cardiovascular risk

Dec. 3, 2021
By Anette Breindl
In the December 3, 2021, issue of Science, researchers reported that a missense variant that is highly enriched in the Amish population was associated with reduced levels of both LDL cholesterol and fibrinogen. To date, very few variants have been identified that affect more than one risk factor for cardiovascular disease.
Read More
Neurology illustration

DREADD approach calms neuropsychiatric dread circuits in primates

Dec. 2, 2021
By Anette Breindl
Investigators at the University of Wisconsin have decreased anxiety-related behaviors in monkeys with an anxious temperament by treating them with a combination of gene therapy and low doses of the atypical antipsychotic drug clozapine, which is approved for the treatment of schizophrenia and schizoaffective disorder.
Read More
Coronavirus, lungs, hand holding stethoscope

Strategy elicits broad immunity against respiratory viruses

Dec. 1, 2021
By John Fox
Stimulating the innate immune system with defective viral genomes (DVG)-based strategy provided broad-spectrum protection against RNA viral infections, including SARS-CoV-2 and other respiratory diseases in animal models, according to a U.S.-led international collaborative study reported in the Nov. 17, 2021, edition of Cell.
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Hands holding petri dish

B-cell targeting controls chronic viral infections in mice

Nov. 30, 2021
By John Fox
Targeting the epigenetic histone modifier BMI-1 in B cells restored effective humoral immune responses to control chronic viral infection in mice, according to new multicenter Australian study led by immunologists at Monash University in Melbourne, Victoria.
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Pancreas illustration

Targeting senescent cells may fight insulin resistance

Nov. 29, 2021
By John Fox
Investigators have identified a previously unrecognized population of senescent cells, called p21high cells, in fat tissue and demonstrated their contributory role in metabolic dysfunction, obesity, insulin resistance and type 2 diabetes.
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Large intestine illustration

Probiotic strategy prevents Enterococcus escape from the gut

Nov. 24, 2021
By Anette Breindl
“I was not always someone who would have advertised probiotics,” Michael Otto told BioWorld. And it’s easy to see why. At this point, probiotics are more often dubious wellness offerings than evidence-based therapeutics. Part of the issue is that the mechanisms by which probiotics are supposed to exert their effects are mostly vague. Molecular mechanisms that could account for claimed health benefits are few and far between. But Otto, who is chief of the pathogen molecular genetics section at the National Institutes of Allergy and Infectious Disease, and his colleagues have identified one such molecular mechanism.
Read More
Neurons

Preclinical Alzheimer's vaccine, therapy target soluble amyloid

Nov. 24, 2021
By John Fox
A newly developed antibody-based treatment and a protein-based vaccine for Alzheimer's disease (AD) have both been shown to reduce AD symptoms in mouse models of the disease, British and German researchers reported in the November 15, 2021, edition of Molecular Psychiatry.
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B-cell GABA release blunts tumor immune response

Nov. 23, 2021
By John Fox
Immune system B cells secrete the neurotransmitter gamma amino-butyric acid (GABA), which promotes generation of anti-inflammatory macrophages and blunts the cytotoxic T cell-based response to tumors in mice.
Read More
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