Investigators at Boston Children's Hospital have demonstrated that SARS-CoV-2 infection of blood monocytes and lung macrophages in the lung could kill the cells via pyroptosis, increasing inflammation and leading to severe COVID-19.
There is a project management joke that the first 90% of a project takes 90% of the time, whereas the last 10% of the project takes the other 90% of the time.
The mammalian target of rapamycin (mTOR) inhibitor rapamycin extended the lifespan of female but not male flies, through sex-specific effects on the enterocytes that line the gut.
A team of scientists led by Liang Ge from Tsinghua University have identified a chaperonin subunit CCT2 as a new type of aggrephagy receptor which specifically accelerates the autophagic clearance of solid aggregates independent of ubiquitination, providing a promising therapeutic target for neurodegenerative diseases.
There is a project management joke that the first 90% of a project takes 90% of the time, whereas the last 10% of the project takes the other 90% of the time.
There is a project management joke that the first 90% of a project takes 90% of the time, whereas the last 10% of the project takes the other 90% of the time.
Scientists at the University of Connecticut have made progress in understanding the role of the targetable TRPM2 channel in the context of atherosclerosis, as they report in the March 28, 2022, issue of Nature Cardiovascular Research.
Investigators at the National Institute of Biological Sciences in Beijing and China Agricultural University have identified mixed lineage kinase domain-like protein as an important player in diabetic neuropathy.
A multidisciplinary team of scientists has discovered the mechanism that controls synaptic pruning of new neurons in the adult brain. The team discovered that microglial cells control the number of synapses by "eating" excessive synapses.
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