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BioWorld - Wednesday, June 11, 2025
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DNA sequence and COVID-19 virus cells

Gene in 60% of people of South Asian ancestry doubles the risk of COVID-19 death

Nov. 9, 2021
By Nuala Moran
LONDON – Researchers have pinpointed a little-studied gene as responsible for doubling the risk of respiratory failure in COVID-19 and shown exactly how it exerts its effect. The gene, leucine zipper transcription factor like 1, is activated by a single base pair change on chromosome 3 that occurs in 60% of people of South Asian ancestry and 15% of people of European ancestry.
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Fluorescence microscopy image of mitochondria

Parkinson’s disease model confirms metabolic, contests anatomic tenets

Nov. 9, 2021
By Anette Breindl
Investigators at Northwestern University’s Feinberg School of Medicine have used a new mouse model of Parkinson’s disease to confirm a causal role for mitochondrial dysfunction in Parkinson’s disease. More surprisingly, the same model has called into question previously uncontroversial notions about the motor features that are PD’s most conspicuous feature.
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Viruses-infecting-neurons.png
Virtual Neuroscience 2021

Brain infections rare but brain symptoms common with SARS-CoV-2

Nov. 9, 2021
By Anette Breindl
The sprint of fighting COVID-19 has been in respiratory medicine. For patients who become acutely ill, the short-term danger is in respiratory failure. But increasingly, it seems like the pandemic’s marathon fight may come to be against the neurological symptoms of COVID-19.
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Antibody-drug conjugate

Antibody discovery platform increases cancer immunotherapy targets

Nov. 8, 2021
By John Fox
An international study led by U.S. oncologists at Children's Hospital of Philadelphia has successfully used a new antibody discovery platform developed by Myrio Therapeutics of Melbourne, Australia, to help identify and target key drivers of neuroblastoma in mouse models, the authors reported in the November 3, 2021, issue of Nature.
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DNA sequence and COVID-19 virus cells

Gene in 60% of people of South Asian ancestry doubles the risk of COVID-19 death

Nov. 5, 2021
By Nuala Moran
LONDON – Researchers have pinpointed a little-studied gene as responsible for doubling the risk of respiratory failure in COVID-19 and shown exactly how it exerts its effect. The gene, leucine zipper transcription factor like 1, is activated by a single base pair change on chromosome 3 that occurs in 60% of people of South Asian ancestry and 15% of people of European ancestry.
Read More
Fluorescence microscopy image of mitochondria

Parkinson’s disease model confirms metabolic, contests anatomic tenets

Nov. 4, 2021
By Anette Breindl
Investigators at Northwestern University’s Feinberg School of Medicine have used a new mouse model of Parkinson’s disease to confirm a causal role for mitochondrial dysfunction in Parkinson’s disease. More surprisingly, the same model has called into question previously uncontroversial notions about the motor features that are PD’s most conspicuous feature.
Read More
DNA on digital background

Computational prodding of evolutionary history gives clues to gene variants

Nov. 4, 2021
By Anette Breindl
By using an unsupervised machine learning approach to look at genetic variation across the protein-coding genomes of 140,000 species, researchers at Harvard Medical School and Oxford University have developed a new variant classifying system that performed on a par with wet lab approaches.
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Pills and bottle

New treatment targets identified in opiate abstinence

Nov. 3, 2021
By John Fox

A study led by researchers at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has shown that amygdala kappa-opioid receptor-dependent upregulation of glutamate transporter 1 mediates depressive-like behaviors in mouse models of opiate abstinence.


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Skin irritation on hands

Studies show that psoriasis is more than skin-deep

Nov. 2, 2021
By Anette Breindl
At a recent lecture at the U.S. National Institutes of Health, Mehta, who is chief of the laboratory of inflammation and cardiometabolic diseases at the National Heart Lung and Blood Institute and an adjunct professor of medicine at George Washington University, described his insights into the links between psoriasis, inflammation and cardiometabolic disease.
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Neuron

Gene therapy provides pain relief by resetting "corrupted" circuit

Oct. 29, 2021
By Anette Breindl
By increasing the expression of the chloride transporter Kcc2 (K-Cl cotransporter 2), researchers at Duke University have reduced chronic pain in mouse models of nerve pain and bone cancer.
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