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BioWorld - Thursday, July 10, 2025
Home » Topics » Science » Omics

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Two silhouettes with tangle, gear, spiral

Dissecting post-traumatic stress disorder and depression

May 31, 2024
By Mar de Miguel
Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder and major depressive disorder, among others.
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Two silhouettes with tangle, gear, spiral
Neurology/psychiatric

Dissecting post-traumatic stress disorder and depression

May 28, 2024
By Mar de Miguel
Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), among others.
Read More
3D cross-section illustration of muscle anatomy
Aging

Preserving autophagy protects from muscle aging

April 26, 2024
By Mar de Miguel
A protein whose expression decreases during aging could be key to preserving cellular maintenance mechanisms and preventing the progressive loss of muscle mass that occurs during aging. Scientists from the Institute for Research in Biomedicine (IRB) and the University of Barcelona (UB) have revealed the role of the TP53INP2 protein in autophagy and the effects of its reduction on skeletal muscle during aging.
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Art concept for pangenome wrapping around the globe

In 2023, big projects create ‘satellite maps’ of cell biology

Jan. 9, 2024
By Mar de Miguel
If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023.
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Art concept for pangenome wrapping around the globe

In 2023, big projects create ‘satellite maps’ of cell biology

Jan. 5, 2024
By Mar de Miguel
If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023. From the generation of the human pangenome to cell-by-cell maps of the brain and kidneys, scientists this year have completed several omics collaborative projects stored in large international databases. Now, what’s the plan?
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Art concept for pangenome wrapping around the globe
’23 in review

In 2023, big projects create ‘satellite maps’ of cell biology

Dec. 29, 2023
By Mar de Miguel
If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023. From the generation of the human pangenome to cell-by-cell maps of the brain and kidneys, scientists this year have completed several omics collaborative projects stored in large international databases. Now, what’s the plan?
Read More
Brain map visualization of the neurological differences between two people.
Neurology/Psychiatric

Building the map for every cell of the human brain

Oct. 25, 2023
By Mar de Miguel
To understand the human brain, an international consortium of scientists has created the most complete atlas of this organ to date. The map reveals the anatomy, the architecture of the tissues, how or where each cell is, their function, gene expression and regulation. On Oct. 12, 2023, Science and Science Advances published a group of 21 studies that unveiled the map of the human brain, as well as the brains of nonhuman primates and mice, cell by cell, for an adult model and for the different stages of development.
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3D rendered illustration of the anatomy of a cancer cell
Cancer

Pan-cancer studies take pan-oramic view on proteogenomics

Aug. 22, 2023
By Mar de Miguel
The vast variety of tumors makes each cancer a world. For researchers, understanding the commonalities and divergences in their molecular underpinnings could help find successful treatments. Scientists from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) have addressed these similarities and differences in 10 different types of cancer with two proteogenomic studies to unravel the genes that lead to cancer and the galaxy of interactions that regulate them.
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3D rendered illustration of the anatomy of a cancer cell
Cancer

Pan-cancer studies take pan-oramic view on proteogenomics

Aug. 21, 2023
By Mar de Miguel
The vast variety of tumors makes each cancer a world. For researchers, understanding the commonalities and divergences in their molecular underpinnings could help find successful treatments. Scientists from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) have addressed these similarities and differences in 10 different types of cancer with two proteogenomic studies to unravel the genes that lead to cancer and the galaxy of interactions that regulate them.
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Endocrine/Metabolic

Building a better, biological, BMI

March 22, 2023
By Anette Breindl
Body mass index (BMI), which is calculated from height and weight, and its relationship to health is a hotly debated area of health. On the one hand, “it’s cheap, it’s intuitive, it’s noninvasive and easy to calculate,” Noa Rappaport told BioWorld. “But it misses a lot.” In the March 20, 2023, online issue of Nature Medicine, Rappaport’s group describes an alternative measure, which they have termed the biological BMI, that “better reflects metabolic health than traditional BMI,” said Rappaport, who is a senior research scientist at the Institute for Systems Biology and the paper’s corresponding author.
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