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Home » Topics » Omics » Genomics

Genomics
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Group of kids, faces huddled together
Genetic/congenital

UK releases three decades of children’s genomic data

March 5, 2025
By Nuala Moran
The U.K. has released a huge repository of children’s genomic data after sequencing blood samples from three large cohorts recruited at birth and followed across three decades. The power of the data is amplified by the large volume of longitudinal health information, biological samples and responses to surveys and questionnaires that has been provided by participating families. Before this, large-scale publicly available genome sequences were limited to adult cohorts, and the only childhood genome sequence data was from children with rare diseases.
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DNA, RNA concept art.
Drug design, drug delivery & technologies

Genomic study paves way for multimorbidity treatments

Feb. 10, 2025
By Nuala Moran
A large-scale study cross-referencing genomic data from multiple sources with primary care health records has identified genetic overlaps in 72 chronic diseases, opening the way for a more holistic approach to researching, treating and preventing multimorbidity.
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The DNA double helix overlays a field of ACGTs and binary numbers.
Endocrine/metabolic

Study finds genetic factors behind early-onset type 2 diabetes in South Asians

Dec. 3, 2024
By Nuala Moran
A U.K. study has uncovered distinctive genetic drivers of type 2 diabetes in South Asians that lead to faster development of complications, the need for earlier insulin replacement therapy and a weaker response to some widely prescribed drugs. That points to the need to refine care pathways. But in addition, the research provides a potent illustration of how the under-representation in genomics databases of people who are not of white European origin can skew results and be a source of discrimination.
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13-lined-ground-squirrel.jpg

Through comparative genomics, becoming tough as nails – or squirrels

Jan. 30, 2024
By Anette Breindl
Humans love to think of our species as unique. But on a genetic level, such uniqueness is surprisingly hard to find. And while that may be a blow to the ego, it also means that an evolutionary lens is one way to search for insights into human diseases. Animals are “adapted to use the same genes that you and I have, but in very different ways,” Ashley Zehnder told BioWorld. Zehnder is co-founder and CEO of Fauna Bio Inc., which uses comparative genomics to identify gene networks that underlie disease resistance in different animal species.
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Art concept for pangenome wrapping around the globe

In 2023, big projects create ‘satellite maps’ of cell biology

Jan. 9, 2024
By Mar de Miguel
If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023.
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Art concept for pangenome wrapping around the globe

In 2023, big projects create ‘satellite maps’ of cell biology

Jan. 5, 2024
By Mar de Miguel
If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023. From the generation of the human pangenome to cell-by-cell maps of the brain and kidneys, scientists this year have completed several omics collaborative projects stored in large international databases. Now, what’s the plan?
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Art concept for pangenome wrapping around the globe
’23 in review

In 2023, big projects create ‘satellite maps’ of cell biology

Dec. 29, 2023
By Mar de Miguel
If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023. From the generation of the human pangenome to cell-by-cell maps of the brain and kidneys, scientists this year have completed several omics collaborative projects stored in large international databases. Now, what’s the plan?
Read More
Cells and DNA helix
Genetic/Congenital

‘A trillion in each of us’: Flagship-backed Quotient takes on somatic genomics

Nov. 29, 2023
By Jennifer Boggs
Launching a company based on knowledge that “the fundamental principle that most people hold to be true is off by a trillion” is a rare opportunity, said Jake Rubens, co-founder and president of Quotient Therapeutics Inc., a company that emerged from stealth this week, backed by two years of platform development and a $50 million investment from Flagship Pioneering.
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Cells and DNA helix
Newco news

‘A trillion in each of us’: Flagship-backed Quotient takes on somatic genomics

Nov. 22, 2023
By Jennifer Boggs
Launching a company based on knowledge that “the fundamental principle that most people hold to be true is off by a trillion” is a rare opportunity, said Jake Rubens, co-founder and president of Quotient Therapeutics Inc., a company that emerged from stealth this week, backed by two years of platform development and a $50 million investment from Flagship Pioneering.
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Illustration showing pangenome graph
Genetic/Congenital

Pangenome gives more panoramic view of human diversity

May 10, 2023
By Mar de Miguel
The human genome, the sequence that represents the DNA of our species, was built with a single individual as a model. This all-in-one standard didn’t include the gene variations that make us different or explain why some people develop certain diseases. Four simultaneous studies from the Human Pangenome Reference Consortium have published a sequence based on 47 individuals, beginning to capture the genetic diversity that defines humans.
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