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Home » Topics » Science » Stem cells

Stem cells
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Concept art for stem cell implantation

Stem cell therapies show safety in clinical trials in Parkinson's

April 16, 2025
By Mar de Miguel
Stem cell implantation is a step closer to becoming the next strategy against Parkinson's disease. Two clinical trials, one in phase I and the other in phase I/II, have demonstrated their safety and potential to restore dopamine production in the brains of patients with this currently incurable neurodegenerative condition. The number of participants in the study is still small, and further research is needed to demonstrate the clinical benefits of these cell therapies.
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3D illustration of brain cancer

Quiescent, but not quiet, cancer stem cells in glioblastoma relapse

Nov. 13, 2024
By Mar de Miguel
Six main cell types form glioblastomas, the most aggressive brain cancer due to its high rate of recurrence. Of these six, quiescent cancer stem cells are responsible for resistance to therapy and the reappearance of the tumor, according to a study that identified the six groups and highlighted the importance of these stem cells for the design of more effective therapies.
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3D illustration of brain cancer
Cancer

Quiescent, but not quiet, cancer stem cells in glioblastoma relapse

Nov. 12, 2024
By Mar de Miguel
Six main cell types form glioblastomas (GBM), the most aggressive brain cancer due to its high rate of recurrence. Of these six, quiescent cancer stem cells are responsible for resistance to therapy and the reappearance of the tumor, according to a study that identified the six groups and highlighted the importance of these stem cells for the design of more effective therapies.
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Hair follicle containing phagocytic stem cells
Dermatologic

Stem cells eat dead cells to ensure tissue integrity

Aug. 28, 2024
By Mar de Miguel
Phagocytosis – eliminating millions of dead cells every day – requires specialized cells such as macrophages, the true professionals, which migrate to engulf waste and dying cells.
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Hair follicle containing phagocytic stem cells
Dermatologic

Stem cells eat dead cells to ensure tissue integrity

Aug. 27, 2024
By Mar de Miguel
Phagocytosis – eliminating millions of dead cells every day – requires specialized cells such as macrophages, the true professionals, which migrate to engulf waste and dying cells. But they are not the only ones that can perform this task, as scientists at Howard Hughes Medical Institute (HHMI) discovered when they investigated hair follicle stem cells (HFSCs), a tissue in constant regeneration, to clarify how dying cells are detected and cleared in the epithelium and the mesenchyme.
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Photo of jellyfish in aquarium lit by blue light
Aging

Jellyfish genes rejuvenate intestinal stem cells in fruit flies

Aug. 13, 2024
By Tamra Sami
Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.
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Photo of jellyfish in aquarium lit by blue light
Aging

Jellyfish genes rejuvenate intestinal stem cells in fruit flies

Aug. 7, 2024
By Tamra Sami
Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.
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Stem cells
Neurology/psychiatric

ISSCR 2024: Expanding niche definition gives insights into stem cells

July 16, 2024
By Anette Breindl
The word “niche” implies a specialized environment. But to Fiona Doetsch, the stem cell niche is anything but. For brain stem cells, “the whole organism is the niche,” Doetsch told the audience at the third plenary session of the International Society for Stem Cell Research (ISSCR) annual meeting in Hamburg this week.
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Stem cells

ISSCR 2024: Expanding niche definition gives insights into stem cells

July 15, 2024
By Anette Breindl
The word “niche” implies a specialized environment. But to Fiona Doetsch, the stem cell niche is anything but. For brain stem cells, “the whole organism is the niche,” Doetsch told the audience at the third plenary session of the International Society for Stem Cell Research (ISSCR) annual meeting in Hamburg this week. It’s a surprising idea at first, given the brain’s protection from many circulating substances via a series of barriers, including the blood-brain barrier and the blood-cerebrospinal fluid barrier.
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Cell research illustration
Musculoskeletal

ISSCR 2024: iPS cell line panels can be isogenic and diverse

July 15, 2024
By Anette Breindl
The big advantage of cell culture to model diseases is its throughput. “You can play the disease over and over again in the dish,” Clive Svendsen told the audience at the International Society of Stem Cell Research (ISSCR) Annual Meeting held in Hamburg last week. That high throughput, however, is not particularly useful if the cell lines themselves do not accurately model the disease. Cancer cell lines are used in many cell culture experiments far beyond cancer for their ability to grow. But they are “highly abnormal,” Bill Skarnes told the audience at an innovation showcase, as well as quite unstable. “I don’t think the [HEK-293] cell line is the same in your lab as it is in the lab next door,” Skarnes said.
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