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Home » Topics » Clinical

Clinical
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Molecular Targets Meeting 2019

Bispecific matchmakers can improve antibodies, CARs

Oct. 29, 2019
By Anette Breindl
BOSTON – Researchers from Memorial Sloan-Kettering Cancer Center presented encouraging, though very early, data on Merus NV's bispecific antibody MCLA-128 for the treatment of patients with NRG-1 gene fusions at the AACR-NCI-EORTC Molecular Targets meeting on Sunday.
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Pfizer tracking lung cancer resistance profile using Inivata's liquid biopsy tool

Oct. 29, 2019
By Nuala Moran
LONDON – Pfizer Inc. is taking further steps to distinguish its third-generation anaplastic lymphoma kinase (ALK) inhibitor, Lorbrena, from the rest of the field, funding a pan-European trial that will use liquid biopsies to track the resistance profile of non-small-cell lung cancers (NSCLC).
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Takeda reports positive phase III data for eosinophilic esophagitis candidate

Oct. 29, 2019
By Michael Fitzhugh
A late-stage test of Takeda Pharmaceutical Co. Ltd.'s oral suspension of the steroid budesonide for the treatment of eosinophilic esophagitis (EoE) achieved both its co-primary endpoints, improving histologic and dysphagia symptom responses vs. placebo during the first pivotal phase III study of an EoE treatment ever to be reported in the U.S. The study, part of the largest EoE clinical program globally to date, also met secondary endpoints, including improvements from baseline to final treatment as measured by an established patient-reported outcome measurement.
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What it's looking for: TG to find CLL victory in U2? Follicular win lifts case

Oct. 29, 2019
By Randy Osborne
As TG Therapeutics Inc.'s phase IIb win in the follicular lymphoma (FL) cohort of the Unity-NHL pivotal experiment testing umbralisib charmed Wall Street, CEO Michael Weiss told investors that the New York-based company is "completely committed to getting our marginal zone lymphoma [MZL] filing in on time and getting to the market" soon. Nobody's forgetting about the opportunity in chronic lymphocytic leukemia (CLL), either.
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Eye chart

Iveric's positive top-line data for macular degeneration brings its stock into focus

Oct. 29, 2019
By Lee Landenberger
Upbeat top-line data for New York-based Iveric Bio Inc.'s phase IIb trial testing Zimura in dry age-related macular degeneration propelled the company stock (NASDAQ:ISEE) 82.8% upward in Monday's trading, a big success in a company that rebranded itself earlier this year.
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Mighty mitomycin instills hope in bladder, urothelial as Urogen NDA underway

Oct. 28, 2019
By Randy Osborne
With Stifel analysts recently setting a $41 price target for Urogen Pharma Ltd. and interim data in hand from the trial in bladder cancer with UGN-102, hopes are high that the drug's approach – having already proved its mettle in UGN-101 against low-grade upper tract urothelial cancer (UTUC) – will yield durable results. Shares (NASDAQ:URGN) have been trading at around $22, closing Friday at $21.97.
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Study shows readmission rate for HF patients slashed using lung fluid measuring device

Oct. 25, 2019
By David Godkin
TORONTO – Winnipeg, Manitoba-based Medicure Inc. said results of a study released last week could nudge the door open wider in the U.S. for a device adapted from the military to normalize lung fluid content in patients suffering from heart failure.
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Provention's Crohn's disease inhibitor suffers placebo effect

Oct. 23, 2019
By Lee Landenberger
Despite Provention Bio Inc.'s phase IIa top-line data showing PRV-6527 in Crohn's disease did not differentiate from placebo, the company's stock was bumped back less than 1% on Tuesday as it continued to ride high after June's massive leap on heartening data about the company's type 1 diabetes trial of teplizumab.
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Silhouette with keyhole

No 'adieu' for adu just yet, FDA Engage-ment still on; Biogen to Emerge winner?

Oct. 23, 2019
By Randy Osborne
Biogen Inc.'s decision to file for approval early next year of beta-amyloid-targeting aducanumab (adu) in Alzheimer's disease (AD) based on fresh analysis of a bigger phase III dataset juiced the stock and induced shock at the same time, as Wall Street pressed company officials for details on their rationale behind the move.
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Helixmith points to success in VM-202 phase III-Ib trial, though investors skeptical

Oct. 23, 2019
By Jihyun Kim
HONG KONG – South Korea's Helixmith Co. Ltd. has announced the results of a phase III trial extension testing VM-202 (donaperminogene seltoplasmid), a regenerative plasmid DNA gene therapy candidate, in diabetic peripheral neuropathy (DPN).
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