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BioWorld - Tuesday, April 14, 2026
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Novartis sells India subsidiary to private equity firm for $159M

Feb. 23, 2026
By Marian (YoonJee) Chu
No Comments
Swiss pharmaceutical giant Novartis AG is selling off its India-listed business unit, Novartis India Ltd. (NIL), to a private equity-led consortium for about ₹14.46 billion (US$159.3 million) as it seeks to grow with “pure-play innovation.”
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Cancer

French researchers patent cathepsin D inhibitors

Feb. 23, 2026
Apmonia Therapeutics SAS, the Centre National de la Recherche Scientifique and the Université de Reims Champagne Ardenne have disclosed LRP1-derived polypeptides acting as cathepsin D (CTSD) inhibitors.
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Cancer

New TNF-α modulators disclosed in Sanofi/UCB patent

Feb. 23, 2026
Sanofi SA and UCB SA have jointly reported active metabolites of balinatunfib acting as TNF-α modulators.
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Cancer

Bayer identifies SOS1 inhibitors for cancer

Feb. 23, 2026
Bayer AG has synthesized new son of sevenless homolog 1 (SOS1) inhibitors reported to useful for the treatment of cancer.
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Colorectal cancer 3D illustration
Immuno-oncology

L. monocytogenes vaccine enhances immunotherapy efficacy in CRC

Feb. 23, 2026
No Comments
In a recent study, researchers from Stony Brook University Renaissance School of Medicine and Cold Spring Harbor Laboratory investigated whether in vivo targeting of gastrointestinal tissues via foodborne delivery of Lm-based cancer vaccines could control tumor growth in murine models of colorectal cancer.
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Eye and DNA
Cancer

CRISPR-Cas13d-mediated targeting of RasGRP3 shows selective anticancer effects in uveal melanoma

Feb. 23, 2026
No Comments
A new study by researchers at Stanford University and collaborating institutions aimed to investigate the safety and efficiency of lipid nanoparticle-mediated Cas13d mRNA delivery to uveal melanoma cells.
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Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Immuno-oncology

First-in-class LTβR x EDB bispecific antibody overcomes checkpoint resistance

Feb. 23, 2026
No Comments
Researchers from Agni Bio Inc. reported the preclinical profile of AGB-201, a bispecific antibody designed to simultaneously target EDB and LTβR, while minimizing unwanted immune activation.
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T cells
Immuno-oncology

Zelluna’s ZI-MA4-1 gains UK CTA clearance for solid tumors

Feb. 23, 2026
No Comments
Zelluna ASA has received approvals from the U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA) and research ethics committee for its clinical trial application (CTA) for ZI-MA4-1, Zelluna’s lead T-cell receptor-based natural killer (TCR-NK) product candidate.
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Grail Galleri multicancer early detection test

Grail shares plunge after Galleri test misses primary endpoint

Feb. 20, 2026
By Shani Alexander
No Comments
Grail Inc.’s share price dropped more than 50% in premarket trading Feb. 20 after it reported late the day before that the NHS-Galleri trial did not meet its primary endpoint. The U.K study, done though the National Health Service with 142,000 individuals enrolled, evaluated the ability of Grail’s Galleri multicancer early detection test to look for cancer-specific methylation patterns in blood.
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Cancer

Shanghai Fudan Zhangjiang Biopharmaceutical synthesizes new compounds for cancer

Feb. 20, 2026
Shanghai Fudan Zhangjiang Biopharmaceutical Co. Ltd. has discovered anthracycline compounds potentially useful for the treatment of cancer.
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