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BioWorld - Sunday, March 26, 2023
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

Impact Therapeutics presents new PARP inhibitors for cancer

March 20, 2023
No Comments
Impact Therapeutics (Shanghai) Inc. has divulged substituted tricyclic compounds acting as poly(ADP-ribose) polymerase (PARP; ARTD) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Biofront discovers new HPK1 degradation inducers

March 20, 2023
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Biofront Ltd. has described proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; MEKKK1) targeting moiety via linker acting as HPK1 degradation inducers reported to be useful for the treatment of cancer.
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Immuno-oncology

RP Scherer Technologies patents new antibody-drug conjugates for cancer

March 20, 2023
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RP Scherer Technologies LLC has disclosed antibody-drug conjugates consisting of nectin-4...
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Vaccine vial and syringe
Immuno-oncology

Cancervax's sponsored research program with UCLA on universal cancer vaccine now underway

March 20, 2023
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Cancervax Inc.'s sponsored research program with the University of California Los Angeles (UCLA)...
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Cancer

Macrophages drive invasive breast cancer

March 20, 2023
By Mar de Miguel
No Comments
T cells do not have the last word in some breast cancers. According to a study from the University of Pittsburgh, the key to estrogen receptor positive (ER+) breast tumors are macrophages, not T cells, and targeting them could prevent immunotherapy failure in this type of cancer.
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Cancer

Adlai Nortye Pharmaceutical discovers new CDK12/cyclin K degraders

March 17, 2023
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Adlai Nortye Pharmaceutical Co. Ltd. has described molecular glue degraders acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degraders reported to be useful for the treatment of cancer, viral infections, autoimmune disease and inflammatory disorders.
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Cancer

Janssen Biotech and Yuhan divulge new EGFR mutant inhibitors

March 17, 2023
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Janssen Biotech Inc. and Yuhan Corp. have synthesized substituted aminopyridine compounds acting as EGFR (HER1; erbB1) (mutant) inhibitors reported to be useful for the treatment of cancer and immunological disorders.
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Cancer

Pic Therapeutics patents new eiF4E inhibitors for cancer

March 17, 2023
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Pic Therapeutics Inc. has disclosed eukaryotic translation initiation factor 4E (eiF4E) inhibitors...
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Immuno-oncology

Glenmark’s HPK1 inhibitor GRC-54276 cleared by FDA to enter clinic for advanced solid tumors and lymphomas

March 17, 2023
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Glenmark Specialty SA, a subsidiary of Glenmark Pharmaceuticals Ltd., has received FDA...
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Microscopic image of acute myeloid leukemia (AML) cells.
Cancer

Targeting splicing deregulation in pediatric AML

March 17, 2023
No Comments
Pediatric acute myeloid leukemia (pAML) is a form of cancer that is notorious for high relapse rates...
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