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Home » Topics » Disease categories and therapies » Cancer

Cancer
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Aimedbio’s ₩51B pre-IPO round to fuel new cancer ADCs

June 2, 2025
By Marian (YoonJee) Chu
No Comments
Samsung Medical Center spinoff Aimedbio Inc. announced raising ₩51.1 billion (US$37.15 million) in pre-IPO funding to advance its portfolio of clinical and preclinical antibody-drug conjugate (ADC) candidates.
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ASCO 2025: Regeneron, Merck-Gilead drugs drop disease, death rates

June 2, 2025
By Lee Landenberger
No Comments
New and positive phase III cancer data for two monoclonal antibodies from two pharma giants opened the second day of the American Society of Clinical Oncology (ASCO) conference this past weekend.
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Illustration of cancer cell in crosshairs being destroyed

ASCO 2025: Protagonist-Takeda, Novartis post phase III wins

June 2, 2025
By Lee Landenberger
No Comments
More phase III data coursed through the annual American Society of Clinical Oncology (ASCO) conference on Sunday, as Protagonist Therapeutics Inc. and Takeda Pharmaceutical Co. Ltd. led the charge with positive results for its potential blockbuster rusfertide in treating a rare leukemia.
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ASCO 2025: Pancreatic cancer treatment progressing beyond chemotherapy

June 2, 2025
By Brian Orelli
No Comments
At the 61st American Society of Clinical Oncology (ASCO) Annual Meeting, multiple companies presented clinical trial data showing their drugs and devices helped patients with pancreatic cancer live longer or improve their ability to respond to treatment.
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Green and red bispecific antibodies

Biontech trades half of bispecific BNT-327 to BMS for potential $11B+

June 2, 2025
By Brian Orelli
No Comments
Biontech SE and Bristol Myers Squibb Co. are teaming up to develop Biontech’s BNT-327 in a deal possibly worth over $11 billion. BNT-327 is in the hot new class of bispecific antibodies targeting programmed death-1 (PD-1) or its ligand (PD-L1) and vascular endothelial growth factor (VEGF). The bispecifics take advantage of two well established mechanisms of action that help tumors grow; PD-1/PD-L1, which tells immunogenic T cells not to attack the tumor, and VEGF, which tumors excrete to produce new blood vessels to supply oxygen and other nutrients to the tumor.
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Cancer

Gan & Lee discovers new androgen receptor degradation inducers

June 2, 2025
Gan & Lee Pharmaceuticals Co. Ltd. has described protein cereblon (CRBN) inhibitors and proteolysis targeting chimera (PROTAC) compounds reported to be useful for the treatment of cancer.
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Cancer

Bcl-xl degradation inducers disclosed in Treeline patents

June 2, 2025
Treeline Biosciences Inc. has divulged proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1) targeting moiety via a linker acting as Bcl-xl degradation inducers reported to be useful for the treatment of cancer.
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3D illustration of ovarian cancer cells
Cancer

BNIP3 emerges as a therapeutic target in ovarian cancer

June 2, 2025
No Comments
Among gynecological cancers, ovarian cancer is the deadliest one and with the worst prognosis primarily due to resistance to platinum-based therapies. Esculetin has been shown to exert antitumoral effects in some cancer types, but its effect on ovarian cancer is not well known.
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Cancer

LDHAL6B identified as a prognostic biomarker in multiple myeloma

June 2, 2025
No Comments
Multiple myeloma (MM) is a complex and heterogeneous blood cancer, and current risk assessment tools like the Revised International Staging System (R-ISS) have limitations in accurately predicting prognosis, especially for the intermediate-risk R-ISS II group.
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Lung cancer illustration
Cancer

Long noncoding RNA OIP5-AS1 inhibits lung cancer progression in preclinical studies

June 2, 2025
No Comments
The polarization of macrophages is crucial in modulating the tumor microenvironment and impacting cancer development. Long noncoding RNAs (lncRNAs) have been identified as key regulators in this process.
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