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Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

Genentech discovers new GTPase KRAS mutant inhibitors

June 18, 2025
Genentech Inc. has described GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Shanghai Fosun Pharmaceutical patents new PARG inhibitors

June 18, 2025
Shanghai Fosun Pharmaceutical (Group) Co. Ltd. has synthesized poly(ADP-ribose) glycohydrolase (PARG) inhibitors reported to be useful for the treatment of cancer.
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Microscopic image of acute myeloid leukemia (AML) cells.
Cancer

HPK1 inhibitor BGB-15025 exerts antileukemic activity in mice

June 18, 2025
No Comments
Despite an initial complete remission of 60%-80% in patients receiving anthracycline/cytarabine induction, acute myeloid leukemia (AML) shows a suboptimal long-term outcome rate. Serine/threonine kinase HPK1 has emerged as a promising therapeutic target, demonstrating pan-cancer prognostic significance.
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Cancer

Innovo’s INNO-220 exerts antitumoral activity against lymphoma cells

June 18, 2025
No Comments
B-cell lymphoma represents about 85% of non-Hodgkin lymphoma cases; therapeutic approaches are represented by Bruton tyrosine kinase (BTK) inhibitors, but still some issues, such as drug resistance and off-target toxicity, limit the clinical benefits.
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Cancer tumor in breast illustration
Biomarkers

miR-7974 is a predictor of poor survival in ER+ breast cancer

June 18, 2025
No Comments
Estrogen receptor-positive (ER+) breast cancer remains a major challenge even with well-defined treatment options. The identification of reliable markers for early detection of the disease is crucial for improving patient outcomes.
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Illustration of cancer tumor on pancreas
Immuno-oncology

Medicovestor’s Adobind MC-001 awarded US orphan drug designation

June 18, 2025
No Comments
Medicovestor Inc.’s Adobind MC-001 has been awarded orphan drug designation by the FDA for the treatment of pancreatic cancer. Adobind MC-001 is a chemoimmunotherapy antibody-drug conjugate that integrates proprietary enhancements to antibody structure, payload delivery and tumor engagement.
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Hand holding radioactive symbol
Immuno-oncology

Naya Therapeutics unveils GPC3-targeted Astatine-211 α radioimmunotherapy

June 18, 2025
No Comments
Naya Therapeutics Inc. is expanding its hepatocellular carcinoma pipeline with the addition of NY-700, a first-in-class GPC3-targeted Astatine-211 (211At) α radioimmunotherapy aiming to address residual disease, micro-metastasis and post-immunotherapy failures.
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Antibody-drug conjugate illustration
Immuno-oncology

Sunrock Biopharma and Escugen partner to codevelop CCR9-targeting ADC

June 18, 2025
No Comments
Sunrock Biopharma SL and Shanghai Escugen Biotechnology Co. Ltd. have joined forces in a strategic partnership to codevelop SRB-123, a first-in-class antibody-drug conjugate (ADC) targeting C-C motif chemokine receptor 9 (CCR9), a tumor-associated antigen overexpressed in multiple solid tumors, including pancreatic, ovarian and lung cancer.
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3D representation of tumor microenvironment
Cancer

EACR 2025: Immune rewiring in cancer orchestrates tumor microenvironment

June 18, 2025
By Coia Dulsat
No Comments
Among the presentations included in the Top Abstracts category at the recently inaugurated Annual Congress of the European Association for Cancer Research (EACR) in Lisbon, it is worth highlighting two that respectively addressed the role of cytokines and lipid-sensing receptors as key modulators of the tumor microenvironment, a central theme in current cancer research.
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Deal illustration

Astrazeneca makes $5.3B drug R&D pact with CSPC

June 17, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. announced June 13 that it struck a potential $5.33 billion deal with Astrazeneca plc to develop novel preclinical small-molecule candidates using CSPC’s AI-driven drug development platform.
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