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Home » Topics » Disease categories and therapies » Cancer

Cancer
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Breast cancer illustration
Cancer

MLK3 degrader PROTAC reduces oncogenic potential of TNBC cells

June 20, 2025
No Comments
Researchers from the National Cancer Institute and their collaborators have presented data regarding a MLK3-degrading PROTAC, CEP1347-VHL-02, for treating triple-negative breast cancer.
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Interfering RNA (RNAi)
Cancer

New RNAi targets KRAS G12V using a cancer cell receptor

June 20, 2025
No Comments
An RNA interference (RNAi) molecule that selectively targets the KRAS G12V mutation could represent a key advance in the treatment of cancer associated with this oncogenic variant. Researchers at the University of North Carolina (UNC) at Chapel Hill, in collaboration with Enfuego Therapeutics Inc., have developed a new RNAi designed to enter cells through the epidermal growth factor receptor (EGFR), which is commonly overexpressed in tumor cells. This targeted entry pathway could minimize the side effects associated with therapies that affect KRAS.
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Dendritic cells
Cancer

EACR 2025: A look into next-generation strategies in cancer

June 20, 2025
By Coia Dulsat
No Comments
At the Annual Congress of the European Association for Cancer Research (EACR) in Lisbon, multiple sessions aimed to provide fresh perspectives on the always challenging treatment of cancer, with a strong focus on innovative strategies.
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Cancer

Wuhan Humanwell Pharmaceutical discovers new TEAD inhibitors

June 19, 2025
Wuhan Humanwell Pharmaceutical Co. Ltd. has described heterocyclic compounds acting as transcriptional enhancer factor (TEAD) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Evopoint Biosciences patents new Aurora kinase A degradation inducers

June 19, 2025
Evopoint Biosciences Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an Aurora kinase A (AURKA; ARK1)-targeting moiety through a linker potentially useful for the treatment of cancer.
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Vial and syringe with DNA
Immuno-oncology

DNA vaccine against high-grade serous ovarian cancer

June 19, 2025
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Researchers at Queen’s University of Belfast and collaborators have developed a DNA vaccine against high-grade serous ovarian cancer. The vaccine encodes PRAME, which the researchers found to be upregulated in several cohorts of patients with the malignancy.
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Acute myeloid leukemia illustration
Cancer

BAL-0891 induces potent antileukemic effect in preclinical AML

June 19, 2025
No Comments

Sillajen Inc. has recently presented data regarding their threonine tyrosine kinase (TTK) and Polo-like kinase 1 (PLK1) dual inhibitor BAL-0891 as a therapeutic approach for acute myeloid leukemia (AML) treatment. The compound was tested both in vitro and in vivo in the preclinical setting.


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Cancer

Synfini and O2nix Bio partner on drugs targeting FTSJ1 for cancer metastasis

June 19, 2025
No Comments
Synfini Inc. and O2nix Bio have established a strategic collaboration to co-discover and develop novel drug candidates targeting FTSJ1, a tRNA-modifying enzyme implicated in metastatic cancer cell survival.
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Cancer

AZD-1390 + T-DXd shows synergy reducing tumor growth in TNBC

June 19, 2025
No Comments
About 30%-40% of triple-negative breast cancers (TNBC) show HER2-low status and may benefit from the HER2-directed antibody-drug conjugate trastuzumab deruxtecan (T-DXd). Ataxia-telangiectasia mutated (ATM) kinase plays a crucial role in double-strand break (DSB) repair response, thus inhibitors of ATM, such as AZD-1390, may enhance the effect of DSB inducers, resulting in DNA damage accumulation.
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Cheering Immuneering, Street hopes high in pancreatic

June 18, 2025
By Randy Osborne
No Comments
Immuneering Corp.’s phase IIa data from an ongoing trial in pancreatic cancer disclosed June 17 impressed Wall Street and brought renewed attention to the perennially difficult indication, at which drug developers continue to fling themselves with varied mechanisms.
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