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BioWorld - Sunday, March 26, 2023
Home » Topics » Disease categories and therapies » Cancer

Cancer
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Cancer

Volastra Therapeutics presents new KIF18A inhibitors for cancer

March 22, 2023
No Comments
Volastra Therapeutics Inc. has divulged kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer.
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Cancer

Shanghai Leadingtac Pharmaceutical patents new IRAK-4 degradation inducers

March 22, 2023
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Shanghai Leadingtac Pharmaceutical Co. Ltd. has disclosed proteolysis targeting chimeras...
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Cancer

Potent inhibitor of FAK-mediated signaling shows efficacy in models of TNBC

March 22, 2023
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Researchers from Central South University presented the discovery of novel FAK inhibitors...
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Photomicrograph of hepatocellular carcinoma
Cancer

Rayzebio nominates first-in-class peptide drug candidate against GPC3 for hepatocellular carcinoma

March 22, 2023
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Rayzebio Inc. has nominated a first-in-class novel peptide drug candidate against glypican-3...
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NMPA accepts enfortumab vedotin application from Astellas

March 21, 2023
By Doris Yu
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The NMPA accepted a BLA from Astellas Pharma Inc. for enfortumab vedotin, which is designed for the treatment of patients with locally advanced or metastatic urothelial cancer who previously received treatment with a PD-1/L1 inhibitor and platinum-based chemotherapy.
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Cancer

Biomea Fusion discovers new FLT3 inhibitors for cancer

March 21, 2023
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Biomea Fusion Inc. has described irreversible inhibitors of FLT3 (FLK2/STK1) reported to be useful for the treatment of cancer.
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Cancer

Fibrogen divulges new KDM5 inhibitors

March 21, 2023
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Fibrogen Inc. has synthesized inhibitors of lysine-specific demethylase 5 (KDM5), particularly KDM5B (JARID1B), reported to be useful for the treatment of cancer, anxiety disorder, schizophrenia, viral infection, bipolar disorder, autism, Alzheimer's and Huntington's diseases, among others.
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Cancer

CSPC Megalith Biopharmaceutical patents new antibody-drug conjugates for cancer

March 21, 2023
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CSPC Megalith Biopharmaceutical Co. Ltd. has disclosed antibody-drug conjugates comprising a humanized monoclonal antibody targeting nectin-4 covalently linked to cytotoxic agents through a linker. They are reported to be useful for the treatment of cancer.
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CAR T cell attacking cancer cells
Immuno-oncology

Coimmune exercises option to license IL-18 armored CAR technology from MSK

March 21, 2023
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Coimmune Inc. has exercised its option to obtain an exclusive license to IL-18 armored chimeric antigen receptor (CAR) technology under a prior agreement with Memorial Sloan Kettering Cancer Center (MSK). The company plans to couple the technology with allogeneic cytokine induced killer (CIK) cells to launch the clinical development of CMN-008 (armored CAR-CIK cells), with CD19 as the initial target in B-cell malignancies.
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Cancer cells being destroyed by immunotherapy
Immuno-oncology

Lift demonstrates cytotoxic and immunomodulatory functionalities of IMANp to treat solid tumors

March 21, 2023
No Comments
Lift Biosciences Ltd. has released preclinical data demonstrating that its immunomodulatory alpha neutrophil product (IMANp) possesses both cytotoxic and immunomodulatory functionalities that could signal its potential to cure solid tumors. IMANp is generated from the hematopoietic stem cells of donors with exceptional anticancer innate immunity.
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