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Home » Topics » Disease categories and therapies » Cancer

Cancer
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Digital cardiology illustration
Cancer

ICG-001 protects heart from doxorubicin-induced cardiotoxicity

June 13, 2025
No Comments
Doxorubucin is an effective therapeutic in cancer treatment, but it can cause cardiotoxicity and damage the mitochondrial machinery. A new patient-derived and mitochondria-rich human induced pluripotent stem cell derived-cardiomyocyte (hiPSC-CM) model protected by dexrazoxane was developed.
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Illustration of tumor
Cancer

Aminopyrimidine derivatives against VEGFR-2 in cancer

June 13, 2025
No Comments
Vascular endothelial factor receptor 2 (VEGFR-2) is an attractive target for cancer drugs because inhibiting it prevents tumors from developing the blood vessels that they require for rapid growth. Several VEGFR-2 inhibitors have already been licensed for the clinic.
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Oncolytic virus concept illustration
Immuno-oncology

Dual, tumor-specific TNFR2 and CD47 blockade using an oncolytic virus enhances anticancer immunity

June 13, 2025
No Comments
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide. Recent advancements in immunotherapy have demonstrated the potential of targeting immune checkpoints and co-inhibitory pathways to enhance antitumor responses.
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Immuno-oncology

CD97-targeting CAR T cells with enhanced persistence show promise in AML xenograft models

June 13, 2025
No Comments
Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by the accumulation of immature myeloid cells. Current treatments often fail to achieve durable remission, underscoring the need for innovative therapeutic approaches. CD97 is a cell surface protein with broad, increased expression on AML cells compared to normal blood stem and progenitor cells. Moreover, CD97 overexpression in AML patients has been associated with poor survival, thus emerging as a potential therapeutic target.
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microfluidic patch pump
Patents

Researchers file patent for microfluidic patch-pump drug delivery platform

June 12, 2025
By Simon Kerton
Researchers from Virginia Polytechnic Institute and State University filed for protection of their development of a slim, painless, and affordable microfluidic infusion pump device for the continuous transdermal delivery of drugs.
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Multiple myeloma illustration

Cullinan deals $712M to test Genrix bispecific TCE in autoimmune

June 12, 2025
By Marian (YoonJee) Chu
No Comments
Cullinan Therapeutics Inc. swept up ex-China rights to a multiple myeloma (MM)-targeting BCMAxCD3 bispecific T-cell engager (TCE) velinotamig from Chongqing Genrix Biopharmaceutical Co. Ltd. via a potential $712 million deal June 4. The plan is to repurpose the cancer drug to autoimmune disease.
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Win for ROS1 as Nuvation’s Ibtrozi cleared for NSCLC

June 12, 2025
By Randy Osborne
No Comments
Slightly ahead of the assigned June 23 PDUFA date, Nuvation Bio Inc. scored the U.S. FDA’s go-ahead for Ibtrozi (taletrectinib) to treat adults with locally advanced or metastatic ROS1-positive non-small-cell lung cancer (NSCLC).
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Stock merger illustration

Biontech’s $1.25B Curevac buyout removes mRNA lawsuit uncertainty

June 12, 2025
By Karen Carey
No Comments
Three years after litigation started over technology used in an mRNA vaccine for COVID-19, Biontech SE is acquiring its adversary, Curevac NV, through an all-stock transaction valued at about $1.25 billion. The amount is lower than the $3 billion in backpay Curevac could win through the lawsuit if a low mid-single-digit royalty were awarded, Evercore ISI analysts Jon Miller and Umer Raffat said. But the legal uncertainty has weighed heavily on the company, which shed 30% of its workforce last July and sold off rights to two of its infectious disease vaccines.
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Cancer

Korean scientists discover new USE1 inhibitors

June 12, 2025
Researchers at Korea Research Institute of Chemical Technology and University of Ulsan have described UBA6-specific E2 conjugating enzyme 1 (USE1) inhibitors reported to be useful for the treatment of cancer.
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Infant examination
Cancer

Study unveils cell hierarchies and potential targets in embryonal tumors with multilayered rosettes

June 12, 2025
No Comments
Embryonal tumor with multilayered rosettes (ETMR) is a rare but aggressive brain cancer that affects very young children, typically under the age of 3 years. Survival rates for ETMR patients remain low, with a median survival of just over a year and only about 20% of patients living beyond 5 years.
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