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BioWorld - Monday, December 29, 2025
Home » Topics » Disease categories and therapies » Cardiovascular

Cardiovascular
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GE Healthcare

GE Healthcare taps into Japan radiopharma market with Nihon buy

April 2, 2025
By Marian (YoonJee) Chu
GE Healthcare Technologies Inc. gained full ownership of Nihon Medi-Physics Co. Ltd. after acquiring the remaining 50% stake from Sumitomo Chemical Co. Ltd. on March 31.
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Blue heart and data grid

Edgewise down on atrial fibrillation; cardiomyopathy data positive

April 2, 2025
By Lee Landenberger
Top-line data from the second and third parts of Edgewise Therapeutics Inc.’s four-part phase II Cirrus-HCM study in hypertrophic cardiomyopathy (HCM) has produced more positive data. There was however less enthusiasm for the results than there had been in September for the first batch of data.
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Vaccine vials and syringe in a martini glass.
Cardiovascular

A nanoparticle-based 'cocktail' vaccine against atherosclerosis

April 2, 2025
In a study published in Nature Communications, researchers from Nanjing University present a novel nanovaccine cocktail formulated by individual conjugation of antigen p210 and adjuvant CpG ODNs onto superparamagnetic iron oxide nanoparticles (SPIONs).
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4-9-Abbott-Triclip.png
AAC25

Hospitalizations decline shows clearer benefit in Triclip study

April 1, 2025
By Annette Boyle
The two-year results of TRILUMINATE trial showed the first objective benefit to use of Abbott Laboratories’ Triclip transcatheter tricuspid edge-to-edge repair device in a presentation at ACC.25, the American College of Cardiology’s annual scientific session held March 29-31 in Chicago and simultaneously published in Circulation.
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Edwards-SAPIEN3-12-6.png

Edwards’ Early TAVR refutes surveillance recs for aortic stenosis

April 1, 2025
By Annette Boyle
Don’t wait. Edwards Lifesciences Corp.’s additional insights from the Early TAVR trial showed a clear benefit for transcatheter aortic valve replacement (TAVR) in patients with asymptomatic aortic stenosis.
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Blood pressure gauge, ECG and medication
ACC.25

AI-enhanced ECG readings beat clinicians and labs in identifying MI

March 31, 2025
By Annette Boyle
When every minute matters, quickly determining which patients in the emergency department need urgent care for myocardial infarction can save lives. Researchers at the University Hospital Münster in Münster, Germany, developed a deep learning model that can detect features on electrocardiograms that more accurately identifies which patients require urgent revascularization than clinicians and provides results faster than high-sensitivity troponin lab tests.
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Myst it again: Milestone gets a CRL for its heart spray

March 28, 2025
By Lee Landenberger
Milestone Pharmaceuticals Inc.’s heart rhythm-restoring calcium channel blocker for paroxysmal supraventricular tachycardia (PSVT) has yet another obstacle in its way. 
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Human heart within crosshairs
Cardiovascular

Study identifies CXCR3 as a potential therapeutic target for ICI-induced myocarditis treatment

March 28, 2025
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies activating the immune system to kill tumor cells, representing a major advancement in cancer treatment. However, by activating T-cell immunity, ICI treatment can lead to immune-related adverse events affecting the several organs, including the heart.
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Abbott Labs Volt

Abbott’s Volt enters the PFA fray with CE mark

March 27, 2025
By Annette Boyle
Abbott Laboratories snagged a CE mark for its Volt pulsed field ablation catheter for atrial fibrillation several months earlier than the mid-year approval expected. The Abbott Park, Ill.-based company has begun Volt’s commercial launch with the physicians who participated in its European clinical trials and plans to expand to other users on the continent in the second half of 2025.
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3D dollar sign
Neurology/psychiatric

Augustine Therapeutics closes $85M series A for HDAC6 inhibitors

March 26, 2025
By Nuala Moran
Eight months after announcing the $18.5 million first tranche of its series A, Augustine Therapeutics has closed the oversubscribed round at $85 million and is now ready to begin clinical development of its novel histone deacetylase-6 (HDAC6) inhibitors.
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