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Home » Topics » Disease categories and therapies » Dermatologic

Dermatologic
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Dermatologic

Hepaitech (Beijing) Biopharma Technology discovers new MRGPRX4 antagonists

April 24, 2025
Hepaitech (Beijing) Biopharma Technology Co. Ltd. has described Mas-related G-protein coupled receptor member X4 (MRGPRX4; SNSR5; SNSR6) antagonists reported to be useful for the treatment of anemia, fungal infections, HIV infections, renal disorders, liver diseases, psoriasis, pruritus and urticaria, among others.
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Inflammatory

Aclaris gains IND clearance for bispecific anti-TSLP/IL-4R antibody

April 23, 2025
Aclaris Therapeutics Inc. has gained IND clearance from the FDA for ATI-052, a bispecific anti-thymic stromal lymphopoietin (TSLP)/interleukin-4 receptor (IL-4R) monoclonal antibody being developed to treat certain immuno-inflammatory diseases. A phase Ia/Ib trial, including a proof-of-concept portion in an undisclosed indication, will begin in the current quarter.
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3D illustration of skin layers
Dermatologic

IDOR-1117-2520 shows promise in the treatment of skin autoimmune diseases

April 22, 2025
CC chemokine receptor 6 (CCR6) is a G-protein coupled receptor involved in guiding immune cells through the body and the hallmark receptor for T helper 17 (Th17) cells, and is also expressed in other immune cell populations, such as B cells and innate lymphoid cells, among others.
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Dermatologic

Shanghai Pharmaceuticals describes new CCR4 antagonists

April 16, 2025
Shanghai Pharmaceuticals Holding Co. Ltd. has identified C-C chemokine receptor type 4 (CCR4) antagonists reported to be useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, cancer, systemic lupus erythematosus, rheumatoid arthritis and drug-induced rash. 
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Bradley Burnam, CEO, Turn Therapeutics

Spevigo so-so, innovator takes another Turn at IL-36 in eczema

April 11, 2025
By Randy Osborne
With a promising IL-36 inhibitor for atopic dermatitis (AD, or eczema) at the phase II stage, Turn Therapeutics Inc. has gained $75 million in post-public commitments and meanwhile is pursuing a grassroots strategy to keep the coffers in balance.
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Illustration of interleukin-2 protein structure

IL-2 ADding contenders in eczema strategy

April 10, 2025
By Randy Osborne
The sparsity of mid-to-late stage prospects in atopic dermatitis (AD, or eczema) – which has proved an especially challenging indication – plus some newsmaking fizzles in the space have caused developers to probe new targets with particular intensity. Most popular approaches thus far involve IL-4, IL-13, thymic stromal lymphopoietin and JAK. Developers have stumbled for varying reasons such as high placebo response rates, safety or lack of clinical proof of concept. Among the potential AD rescuers is Nektar Therapeutics Inc. with rezpegaldesleukin (rezpeg), which takes aim at IL-2.
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

Resvita Bio’s RVB-003 designated orphan drug for Netherton syndrome

April 4, 2025
Resvita Bio Inc.’s RVB-003 has been awarded orphan drug designation by the FDA for the skin disorder Netherton syndrome. RVB-003 was previously granted rare pediatric disease designation.
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Dermatologic

JW Pharmaceutical divulges new heterocyclic derivatives for atopic dermatitis

March 31, 2025
JW Pharmaceutical Corp. has synthesized heterocyclic derivatives reported to be useful for the treatment of atopic dermatitis or pruritus.
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Doctor holding illustration of cross section of skin
Dermatologic

Novel selective macrocyclic PKCθ inhibitors for atopic dermatitis and psoriasis

March 28, 2025
At this week’s American Chemical Society Spring meeting, Galderma SA reported the discovery of novel, oral and selective macrocyclic inhibitors of protein kinase C θ (PKCθ) for the potential treatment of atopic dermatitis (AD) and psoriasis.
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Close up of hand scratching arm with psoriasis patches
Dermatologic

Discovery of potent and orally bioavailable IL-17A inhibitors for the treatment of psoriasis

March 21, 2025
Researchers from Anew Therapeutics Pte Ltd. recently detailed the discovery of novel oral IL-17A small-molecule inhibitors as candidates for the treatment of psoriasis.
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