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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
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Illustration of insulin receptors not responding properly to insulin binding
Endocrine/metabolic

Adrenomedullin pathway leads to insulin resistance in obesity

Feb. 12, 2025
By Mar de Miguel
Adrenomedullin, a hormone first identified in an adrenal medullary tumor, disrupts the effect of insulin on the endothelium of blood vessels, leading to insulin resistance linked to obesity and type 2 diabetes. The clue to this discovery lies in a molecular pathway that could be blocked to restore insulin function.
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Gastrointestinal system with ulcerative colitis.
Gastrointestinal

PALI-2108 colon-activated prodrug prevents ulcerative colitis progression

Feb. 11, 2025
Ulcerative colitis is a chronic, immune-mediated disorder of the colon and rectum characterized by mucosal inflammation that damages the bowel wall surface. Current therapeutic options include 5-aminosalicylates, corticosteroids or anti-TNF agents, but there is a need for new strategies to obtain higher remission rates and less systemic immunosuppression.
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Art concept for inflammation in the intestines
Gastrointestinal

Anti-DR3 antibody demonstrates efficacy in the treatment of IBD

Feb. 11, 2025
Death receptor 3 (DR3) is the only signaling receptor for TNF superfamily ligand TL1A, the dysregulation of which has been implicated in multiple inflammatory diseases such as inflammatory bowel disease (IBD). Blockade of TL1A has been shown to induce significant clinical responses in IBD.
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Pancreas
Gastrointestinal

Study HINTs at new target for acute pancreatitis

Feb. 5, 2025
Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox homeostasis, both of which are essential for pancreatic functioning, where oxidative phosphorylation (OXPHOS) plays a crucial role.
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More China ADCs: Arrivent gets GI cancer drug in $1.2B Lepu deal

Feb. 4, 2025
By Marian (YoonJee) Chu
A year after its $175 million IPO in 2024, Arrivent Biopharma Inc. picked up rights to develop and commercialize Lepu Biopharma Co. Ltd.’s antibody-drug conjugate (ADC) candidate, MRG-007, worldwide excluding the greater China region.
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Gastrointestinal

MR-2938 regulates gut microbiota composition and alleviates DSS-induced colitis

Feb. 3, 2025
Researchers from Ocean University of China and Qingdao Marine Science and Technology Center published data from a preclinical study that investigated the impact of the quinazolinone derivative MR-2938 on gut microbiota during colitis. A dextran sodium sulfate (DSS)-induced colitis mouse model was constructed, and the animals were treated with MR-2938 (50 or 100 mg/kg).
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Ayble Health
Patents

Ayble Health’s AI-enabled digital care platform for GI conditions

Jan. 31, 2025
By Simon Kerton
In what represents the first PCT filing emerging in the name of Ayble Health Inc., protection is sought for a system for adaptive, multi-level processing of health data to be used in the individualized management of immune-mediated inflammatory diseases such as inflammatory bowel disease and irritable bowel syndrome.
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3D illustration of pancreatic cancer
Cancer

Combined strategy can prevent pancreatic cancer drug resistance

Jan. 31, 2025
By Mar de Miguel
Understanding the mechanisms of resistance to cancer treatments is necessary to find effective therapies at different stages of the disease. Scientists at UT Southwestern Medical Center studied the most frequent mutation in pancreatic ductal adenocarcinoma (PDAC), identified an escape route to a therapy in clinical trials, blocked it with another experimental compound and reduced tumors in mice.
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Immune cells (red) migrate to the pancreas and stimulate glucagon-producing cells (orange)
Endocrine/metabolic

Neurons send immune cells to the pancreas to regulate glucose

Jan. 30, 2025
By Mar de Miguel
The liver and pancreas are the main actors in glucose metabolism, but not the only ones. Muscles, adipose tissue and the brain play different roles. However, the prize for the best new actor in glucagon production goes to the innate lymphoid cells (ILCs), which, according to a study published in Science, respond to intestine neuron signals traveling to the pancreas to control glucose.
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Gastrointestinal

TLR4 behind severity of ileitis and enteric neuropathy

Jan. 30, 2025
It was hypothesized that the crosstalk between Toll-like receptors, especially Toll-like receptor 4 (TLR4), and serotonergic machinery during inflammation may be an important factor for understanding the neuroimmune mechanisms participating in inflammatory bowel disease pathogenesis.
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