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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
Gastrointestinal RSS Feed RSS

Liver illustration
Gastrointestinal

HDAC6 degrader protects from acute liver injury

Jan. 20, 2025
In the preclinical setting, inhibitors of histone deacetylase 6 (HDAC6) have proven effective at reducing liver inflammation through modulation of the immune response.
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Hand holding radioactive symbol
Gastrointestinal

NIH grant supports evaluation of ghrelin for radiation-induced gastrointestinal syndrome

Jan. 20, 2025
The Feinstein Institutes for Medical Research has been awarded a 5-year, $2.9 million grant from the National Institutes of Health (NIH) to investigate the potential of human ghrelin as a medical countermeasure against radiation-induced gastrointestinal syndrome.
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Hands holding test tubes at laptop
Endocrine/metabolic

Mapping GLP-1RA effects turns up benefits, risks, ‘master lessons in biology’

Jan. 20, 2025
By Anette Breindl
The largest analysis to date of patients taking GLP-1 receptor agonists (GLP-1RAs) has investigated their effects on nearly 175 diseases, and found that compared to three other classes of diabetes medications, individuals with a prescription for GLP-1RAs had a reduced risk of 42 diseases, and an increased risk of 19. The findings, which were published Jan. 20, 2025, in Nature Medicine, provide a comprehensive overview of GLP-1RAs’ effects.
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Pillcam Genius SB capsule endoscopy kit

Medtronic’s Pillcam Genius clarifies GI diagnosis

Jan. 16, 2025
By Shani Alexander
Medtronic plc’s next-generation pill-sized camera saw its first use in a recent appointment, during which it captured thousands of high-definition images of the small bowel mucosa. The company hopes that the new Pillcam Genius SB Kit will transform small bowel diagnostics, as it provides clearer imaging, and greater accessibility and ease for both patients and clinicians.
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EsoCap delivery capsule

Esocap effectively treats eosinophilic esophagitis

Jan. 15, 2025
By Shani Alexander
Esocap AG aims to transform the treatment of eosinophilic esophagitis with its drug delivery technology, ESO-101, designed to increase mucosal contact time and drug deposition in the esophagus. Data from the recent ACESO study showed that ESO-101 was safe and well tolerated and improved both histologic and endoscopic outcomes in patients with active eosinophilic esophagitis.
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Gastrointestinal

Interline Therapeutics divulges new RIPK2 inhibitors for IBD

Jan. 8, 2025
Interline Therapeutics Inc. has synthesized receptor-interacting serine/threonine-protein kinase 2 (RIPK2; RIP-2) inhibitors reported to be useful for the treatment of inflammatory bowel disease (IBD).
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Gastrointestinal

Flagship Pioneering Innovations VI divulges new CD38 inhibitors

Jan. 7, 2025
Flagship Pioneering Innovations VI LLC has synthesized ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) inhibitors.
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Gastrointestinal

Qu Biologics’ Qbeco SSI improves fatty liver disease in mouse model of obesity

Jan. 7, 2025
Qu Biologics Inc. has reported data showing that its Qbeco site specific immunomodulator (SSI) improved fatty liver disease.
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Sequana Medical's Alfapump system

Sequana gets FDA nod for Alfapump to treat patients with ascites

Dec. 30, 2024
By Shani Alexander
Sequana Medical NV received premarket approval from the U.S. FDA for its Alfapump system to treat recurrent or refractory ascites due to liver cirrhosis. Data from the Poseidon pivotal study showed the implantable device, which removes ascites from the abdomen into the bladder, can eliminate the need for therapeutic paracentesis, improving the quality of life of patients.
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Gastrointestinal

KHK inhibitors disclosed in Centennial Therapeutics patent

Dec. 27, 2024
Centennial Therapeutics LLC has divulged ketohexokinase (KHK) inhibitors reported to be useful for the treatment of nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH).
Read More
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