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Home » Topics » Disease categories and therapies » Gastrointestinal

Gastrointestinal
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3D illustration of liver and photomicrograph showing triglyceride fat accumulated in liver cells.
Endocrine/metabolic

ZG-2305 shows efficacy in obesity and fatty liver models

Jan. 29, 2025
Hypoxia-inducible factors (HIFs) are crucial to maintain oxygen homeostasis by regulating cellular metabolic adaptation under hypoxia conditions. Depletion of factor inhibiting HIF (FIH), an enzyme that negatively regulates the activity of the HIF-1α isoform, has been associated with reductions in hepatic steatosis and body mass in mice.
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Liver over digital lens background

Akero’s EFX reverses cirrhosis in MASH patients in phase IIb trial

Jan. 27, 2025
By Jennifer Boggs
What a difference 60 weeks can make. That’s the lesson Akero Therapeutics Inc. shared with the rollout of what executives called “unprecedented” data from the phase IIb Symmetry trial testing efruxifermin (EFX), its FGF21 receptor agonist, in patients with compensated cirrhosis due to metabolic dysfunction-associated steatohepatitis (MASH). While earlier findings had shown only a trend in improvement at 36 weeks, full 96-week results showed more than doubling of earlier effect size, hitting the primary endpoint and sending shares of Akero (NASDAQ:AKRO) up 97% to close Jan. 27 at $51.71.
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Liver disease
Gastrointestinal

TVB-3664 reduces steatosis and inflammation in a MASH model

Jan. 27, 2025
Fatty acid synthase (FASN), an enzyme that drives de novo lipogenesis, plays a relevant role in metabolic disorders such as obesity, non-alcoholic fatty liver disease (NAFLD) or type 2 diabetes. Denifanstat (TVB-2640), a FASN inhibitor, has recently shown positive results in a phase II study in patients with metabolic dysfunction-associated steatohepatitis (MASH).
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Immune cells (red) migrate to the pancreas and stimulate glucagon-producing cells (orange)
Endocrine/metabolic

Neurons send immune cells to the pancreas to regulate glucose

Jan. 27, 2025
By Mar de Miguel
The liver and pancreas are the main actors in glucose metabolism, but not the only ones. Muscles, adipose tissue and the brain play different roles. However, the prize for the best new actor in glucagon production goes to the innate lymphoid cells (ILCs), which, according to a study published in Science, respond to intestine neuron signals traveling to the pancreas to control glucose.
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Endocrine/metabolic

Kexing Biopharm highlights progress across pipeline

Jan. 24, 2025
Kexing Biopharm Co. Ltd. has outlined progress in its cachexia and autoimmune pipelines, built upon its Kx-Body antibody technology platform and Kx-Fusion fusion protein technology platform.
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3D illustration of human digestive system

More China ADCs: Arrivent gets GI cancer drug in $1.2B Lepu deal

Jan. 23, 2025
By Marian (YoonJee) Chu
A year after its $175 million IPO in 2024, Arrivent Biopharma Inc. picked up rights to develop and commercialize Lepu Biopharma Co. Ltd.’s antibody-drug conjugate (ADC) candidate, MRG-007, worldwide excluding the greater China region.
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Colorectal cancer 3D illustration

Vilastobart set apart? Xilio phase II combo performs in CRC

Jan. 22, 2025
By Randy Osborne
“The [colorectal cancer field is moving, and thankfully it’s moving quickly,” said Marwan Fakih, gastrointestinal specialist at City of Hope, speaking about initial phase II data from Xilio Therapeutics Inc.’s ongoing trial with vilastobart (XTX-101) when paired with PD-L1-blocking antibody Tecentriq (atezolizumab, Roche AG) in metastatic microsatellite stable disease.
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More China ADCs: Arrivent gets GI cancer drug in $1.2B Lepu deal

Jan. 22, 2025
By Marian (YoonJee) Chu
A year after its $175 million IPO in 2024, Arrivent Biopharma Inc. picked up rights to develop and commercialize Lepu Biopharma Co. Ltd.’s antibody-drug conjugate (ADC) candidate, MRG-007, worldwide excluding the greater China region.
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Gastrointestinal

CVI Pharmaceuticals describes new THR-β agonists

Jan. 22, 2025
CVI Pharmaceuticals Ltd. has identified thyroid hormone receptor (THR)-β agonists reported to be useful for the treatment of atherosclerosis, hypercholesterolemia, hyperlipidemia, hepatic steatosis, thyroid cancer, obesity and hypothyroidism.
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Gastrointestinal

Antibody Therapeutics patents new integrin receptor antagonists for fibrosis

Jan. 22, 2025
Antibody Therapeutics Inc. has disclosed integrin receptor antagonists reported to be useful for the treatment of pulmonary fibrosis, renal fibrosis and hepatic fibrosis.
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