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Home » Topics » Disease categories and therapies » Genitourinary/sexual function

Genitourinary/sexual function
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Blue and pink illustration of a see-through human head showing brain and glowing endocrine glands and flowing energy lines
Endocrine/metabolic

Study links muscle hormone to reproductive function

Jan. 22, 2025
By Mar de Miguel
A paracrine hormone of skeletal muscle acts as an endocrine signal for the synthesis of a sex hormone. Scientists at McGill University have observed in mice how myostatin, which inhibits the development of muscle mass to control its growth, also stimulated the production of the pituitary follicle-stimulating hormone (FSH), modulating ovarian function. The hypothalamus-pituitary-gonadal axis could include an additional element through a yet unknown role in muscles.
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Ovarian cancer illustration

Drug duo to Repare lack in gyno cancers? Phase I shows promise

Dec. 13, 2024
By Randy Osborne
Wall Street wasn’t jumping up and down about Repare Therapeutics Inc.’s early data in gynecological cancers, though the findings look positive and the company has big plans for the combo therapy.
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Art concept for bladder

Protara, CG climb bladder ladder with SUO cancer findings

Dec. 5, 2024
By Randy Osborne
Among the drug developers with clinical results featured at the annual meeting of the Society for Urologic Oncology (SUO) in Dallas were Protara Therapeutics Inc. with phase II numbers and CG Oncology Inc. with a phase III update. Protara’s shares (NASDAQ:TARA) closed Dec. 5 at $6.02, up $2.48, or 70%, having traded as high as $10.48 during the day. Less reactive was stock in CG (NASDAQ:CGON), which ended at $33.56, down $2.35.
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Kelun Biotech rendering of sacituzumab tirumotecan

China approves Kelun-Biotech’s TROP2 ADC for breast cancer

Dec. 3, 2024
By Marian (YoonJee) Chu
Sichuan Kelun-Biotech Biopharmaceutical Co. Ltd. won local approval of the first China-made trophoblast cell-surface antigen 2 (TROP2)-targeted antibody-drug conjugate (ADC), sacituzumab tirumotecan, as a third-line therapy for advanced breast cancer.
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Kelun Biotech rendering of sacituzumab tirumotecan

China approves Kelun-Biotech’s TROP2 ADC for breast cancer

Dec. 2, 2024
By Marian (YoonJee) Chu
Sichuan Kelun-Biotech Biopharmaceutical Co. Ltd. won local approval of the first China-made trophoblast cell-surface antigen 2 (TROP2)-targeted antibody-drug conjugate (ADC), sacituzumab tirumotecan, as a third-line therapy for advanced breast cancer.
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Woman holding stomach with inflammation
Women's health

Holistic strategies needed to diagnose and treat endometriosis

Nov. 20, 2024
By Tamra Sami
Endometriosis has been woefully under-recognized in the medical community, and consequently, the delay between onset and diagnosis is often quite long, with some women waiting up to 12 years for a diagnosis. Endometriosis affects about 10% of women, and about 190 million women worldwide live with endometriosis.
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Woman holding stomach with inflammation
Healing the health divide

Holistic strategies needed to diagnose and treat endometriosis

Nov. 19, 2024
By Tamra Sami
Endometriosis has been woefully under-recognized in the medical community, and consequently, the delay between onset and diagnosis is often quite long, with some women waiting up to 12 years for a diagnosis.
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Businesswoman pressing dollar sign on touchscreen
Healing the health divide

VCs emerge for women’s health and its ‘groundbreaking’ research

Nov. 15, 2024
By Karen Carey
Despite government efforts to prop up biopharma and med-tech research toward creating women’s health products, companies must eventually reach out to the private markets to bring their inventions to the next stage of development. Anna Zornosa-Heymann, a women’s health investor, serves as a part-time contractor with the U.S. NIH’s SEED (Small business Education & Entrepreneurial Development) office, where she helps companies move from government to external funding. Government funds are “excellent to pay for research … but those funds don’t allow you to build a first-class team and to develop a sales apparatus,” she told BioWorld.
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Endometriosis
Endocrine/metabolic

Blocking CGRP in endometriosis: two birds with one stone?

Nov. 7, 2024
By Coia Dulsat
Researchers at Harvard Medical School have found that blocking the neuron-released peptide CGRP decreases pain sensitivity and reduces lesion size in endometriosis. Endometriosis is a painful, steroid-dependent inflammatory condition in which tissue similar to that of the endometrial lining grows and establishes outside the uterine mucosa.
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Person holding stomach in pain
Newco news

Hope for endometriosis as HMI-115 reduces pelvic pain by 50%

Oct. 29, 2024
By Tamra Sami
Hope Medicine Inc. reported positive interim results for monoclonal antibody HMI-115 in a phase II endometriosis trial that saw the mean non-menstrual pelvic pain score reduced by 50%. “HMI-115 is a prolactin receptor blocker, and we're using it to treat endometriosis and some other diseases. It is a first-in-class new mechanism to treat endometriosis,” Hope Medicine CEO Nathan Chen told BioWorld.
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