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Home » Topics » Disease categories and therapies » Hematologic

Hematologic
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Illustration of mast cell emitting granules
Drug design, drug delivery & technologies

Dual-action synthetic peptides could fight superbugs

June 2, 2025
By Mar de Miguel
No Comments
A peptide with a dual mechanism of action – it dissolves the bacterial membrane and activates the immune system – could be an effective weapon against microorganisms that have evolved ways to evade antibiotics, as superbugs do. Scientists at the University of Pennsylvania (UPenn) have designed stable synthetic peptides that activate mast cell receptors, which are cells involved in the innate and adaptive immune response. This dual approach eliminates bacteria and recruits neutrophils to finish the job.
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Sickle cell illustration
Cancer

Study probes link between sickle cell disease and kidney cancer

May 26, 2025
By Anette Breindl
No Comments
Individuals with both sickle cell disease (SCD) and sickle cell trait are at higher risk than others of developing renal medullary cancer (RMC), the rarest and deadliest subtype of kidney cancer. Researchers at MD Anderson Cancer Center have identified the molecular mechanisms behind the increased risk, gaining new insights into antitumor immunity more generally and, potentially, new ways to treat RMC, and possibly other tumors as well.

SCD “has been studied for 30 years, but 95% of the effort [has been] working on the red blood cells … how red blood cells contribute to hypoxia and then reduce oxygen supply,” Chunru Lin told BioWorld.
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Hematologic

DCN1 and DCN2 inhibitors disclosed in Cellarity patents

May 19, 2025
Cellarity Inc. has divulged DCN1-like protein 1 (DCUN1D1; RP42) and/or DCN2 inhibitors reported to be useful for treatment of sickle cell and thalassemia disorder.
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Art concept for transcription factors binding enhancer sequences
Drug design, drug delivery & technologies

AI-designed DNA allows synthetic control of hematopoiesis

May 9, 2025
By Mar de Miguel
No Comments
Scientists at the Center for Genomic Regulation (CRG) have developed an AI-based tool to design thousands of sequences that regulate DNA. They have also synthesized these molecules, called enhancers, to control gene activation in mouse hematopoietic stem cells, which they have tested in vitro.
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Hematologic

Next-generation inhibitors of factor XIa to treat thrombosis

April 30, 2025
Anticoagulant drugs, whether classical ones such as warfarin and heparin or newer ones such as dabigatran and apixaban, can be effective for treating and preventing deep vein thrombosis, myocardial infarction, ischemic stroke and pulmonary embolisms. Targeting factor XIa, a serine protease in the coagulation pathway, may inhibit thrombosis without increasing bleeding risk. Numerous inhibitors of factor XIa have been developed and several have entered clinical trials, but most have shown problems of poor efficacy, inadequate selectivity or drug-drug interactions.
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Hematologic

Vaccination approach prevents clotting without increased bleeding

April 28, 2025
A recent study by researchers from Texas A&M University presented a new vaccine designed to target the ligand-binding domain of the serotonin 2A receptor (5-HT2AR), which resides in the second extracellular loop (EL2) and was previously identified as the key region for receptor activation. The new candidate, called EL2-5HTVac, was shown to provide a long-lasting and selective therapeutic approach to avoid increased bleeding risk complications.
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Hematologic

New LSD1 inhibitors disclosed in University of Michigan patent

April 17, 2025
The University of Michigan has divulged lysine-specific histone demethylase 1A (KDM1A; LSD1) inhibitors reported to be useful for the treatment of cancer, autism, myocardial fibrosis and more.
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Hematologic

New GlyT-1 inhibitors disclosed in Disc Medicine patent

April 15, 2025
Disc Medicine Inc. has divulged glycine transporter-1 (GlyT-1) inhibitors reported to be useful for the treatment of hematological disorders.
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Red blood cells on blue background
Hematologic

Bayer’s BAY-3389934 allows optimal controllability in sepsis-induced coagulopathy treatment

April 9, 2025
Sepsis-induced coagulopathy (SIC) is a complication of sepsis tied to high mortality in patients. Anticoagulation using a coagulation factor IIa and Xa dual inhibitor might have the potential to improve the treatment of this severe condition.
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Illustration of hole in vessel wall with repair process in progress

Sanofi adds to hemophilia arsenal with FDA nod for Qfitlia

March 31, 2025
By Jennifer Boggs
Sanofi SA gained U.S. FDA approval for fitusiran as a first-in-class siRNA therapy for hemophilia. Branded Qfitlia, the antithrombin-lowering therapy is indicated for use as a prophylactic treatment to prevent or reduce bleeding episodes in people with hemophilia A or B, with or without inhibitors.
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