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Home » Topics » Inflammatory, BioWorld Science

Inflammatory, BioWorld Science
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Cell research illustration
Inflammatory

Immune checkpoint enhancer ALTB-268 decreases inflammation

July 2, 2025
No Comments
Agonists of immune checkpoint modulators for treating autoimmune and inflammatory disorders have shown high potential in immunotherapy. P-selectin glycoprotein ligand 1 (PSGL-1) is known to exert immune checkpoint regulator functions in T cells aside from its classic role as an adhesion molecule involved in leukocyte trafficking.
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Multiple sclerosis
Neurology/psychiatric

At EAN 2025, DEI Hub launches to improve care for all

June 26, 2025
By Anette Breindl
No Comments
In recognition of the fact that diversity, equity and inclusion are necessary prerequisites for precision medicine, the European Academy of Neurology announced the launch of a DEI Hub at its 11th Congress, which is being held in Helsinki through June 24.
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Inflammatory

Sanofi to advance KT-485 into clinic under IRAK-4 partnership with Kymera

June 26, 2025
No Comments
Sanofi SA has selected KT-485 (SAR-447971) to advance into clinical studies under its IRAK-4 partnership with Kymera Therapeutics Inc.
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T cells
Immune

Cue Biopharma holds pre-IND meeting with FDA for lead autoimmune asset

June 25, 2025
No Comments
Cue Biopharma Inc. has received pre-IND feedback from the FDA to discuss the proposed development plan for CUE-401, its lead autoimmune asset. Based on FDA feedback, the company intends to file an IND pending completion of final IND-enabling studies.
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Multiple sclerosis
Neurology/psychiatric

At EAN 2025, DEI Hub launches to improve care for all

June 23, 2025
By Anette Breindl
No Comments
In recognition of the fact that diversity, equity and inclusion (DEI) are necessary prerequisites for precision medicine, the European Academy of Neurology (EAN) announced the launch of a DEI Hub at its 11th Congress, which is being held in Helsinki through June 24. “We know now that when we talk about personalized medicine, we have to understand that talking about stroke, for example, in a woman is different than talking about stroke in a man,” EAN president Elena Moro told the audience at the opening session of the conference.
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Lab glassware and antibodies art concept
Immune

Glucocorticoid ADC targets immune cells in disease models

June 17, 2025
No Comments
Researchers from Lifordi Immunotherapeutics Inc. have developed a novel antibody-drug conjugate (ADC) called LFD-200 that aims to selectively deliver a potent glucocorticoid (GC) payload directly to immune cells. This strategy may potentially offer a new way to treat autoimmune and inflammatory conditions while minimizing systemic toxicity.
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3D illustration of the cross-section of skin layers with atopic dermatitis
Dermatologic

SPT6 maintains epidermal homeostasis in inflammatory skin diseases

June 13, 2025
No Comments
At the ongoing International Society for Stem Cell Research meeting, Chinese researchers reported they demonstrated that SPT6 homolog, histone chaperone and transcription elongation factor (SPT6) promotes epidermal stem/progenitor cells differentiation by facilitating transcriptional elongation, but its role in vivo in skin homeostasis is not well defined.
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Colorized scanning electron microscope image of regulatory T cells and antigen-presenting cells.
Immune

EGL-003 selectively expands Tregs and prevents inflammation

June 12, 2025
No Comments
Regulatory T cells (Tregs) maintain immune homeostasis by inhibiting excessive immune responses. Dysregulation of Tregs, characterized by reduced cell numbers or impaired suppressive function, is implicated in the pathogenesis of autoimmune diseases. Low-dose interleukin-2 (IL-2) therapy expands Tregs and enhances their suppressive capacity while minimizing the activation of T cells and natural killer (NK) cells.
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Molecular research art concept
Inflammatory

Monte Rosa’s molecular glue degrader MRT-8102 gains IND clearance for inflammatory conditions

June 11, 2025
No Comments
Monte Rosa Therapeutics Inc. has gained IND clearance from the FDA for MRT-8102, a NEK7-directed molecular glue degrader being developed to treat inflammatory conditions linked to NLRP3, IL-1β and IL-6 dysregulation.
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Kidneys
Inflammatory

Novel STING antagonist shows robust anti-inflammatory activity

June 10, 2025
No Comments
Persistent activation of the stimulator of interferon genes (STING), resulting from aberrant metabolism or mutations in STING1, can lead to inflammatory damage and autoimmune diseases. Therefore, inhibiting STING activity may offer therapeutic potential for treating these disorders.
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