Researchers have created mouse embryos entirely from stem cells in vitro that formed a brain and a beating heart and lay the foundations for all the other organs of the body.
The synthetic embryos faithfully mimic the development of their natural counterparts in utero for 8.5 days, before hitting a roadblock and becoming disorganized.
Scientists have discovered an RNA-based mechanism that is involved in core hallmarks of a number of accelerated aging conditions and shown that therapies targeting this RNA reverses some of these hallmarks in human cells and extend life spans in mouse models.
The National Institute of Pharmaceutical R&D (Beijing) has described bridged heterocyclyl-substituted pyrimidine compounds acting as tyrosine-protein kinase JAK-1 and/or non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of inflammation, autoimmune disease and cancer.
A new system for restoring cell function and tissues in mammals after death could expand the availability of organs for transplantation. The research also opens up a previously unexplored field of research in the molecular and cellular mechanisms triggered after death, an area of potential significance, since it covers different biological processes with multiple applications.