Incyte Corp. has identified Mas-related G-protein coupled receptor member X2 (MRGPRX2) antagonists reported to be useful for the treatment of inflammatory disorders.
A little-known tissue composed of a cluster of immune cells could offer novel insights into the development of neurological disorders. Meninges' immune system changes with age and neurodegeneration. Are they protecting the brain or fueling disease? Mapping and analyzing the so-called ectopic lymphoid structures (ELSs) in the meninges at different ages in preclinical models of neurodegenerative diseases such as Alzheimer's may help clarify whether they are good, bad, or ugly, as in the iconic film by Sergio Leone.
Quantumpharm Inc., known as Xtalpi Inc., announced receiving $51 million up front from a potential $5.99 billion deal with Dovetree LLC on Aug. 6. The collaboration, first inked through a letter of intent between the two parties on June 23, will combine Shenzhen, China-based Xtalpi’s AI-based and robotics-driven discovery platform with Dovetree’s “biological insights.” The goal will be to select and validate potential first-in-class candidates for Dovetree across five areas of oncology, immunology and inflammatory diseases, neurological disorders and metabolic dysregulation.
The difference between the origin of Alzheimer's disease (AD) and its symptoms is an obstacle to finding effective treatments. Scientists focused on amyloid-β (Aβ) plaques and tau aggregates to slow neurodegeneration and cognitive decline. Without identifying what causes AD, approved treatments do not provide much benefit. However, new findings suggest that restoring lithium levels in the brain could prevent and treat AD. Not just any lithium would work, just the forms that do not bind to Aβ.
Beijing Primegene Therapeutics Co. Ltd. has discovered NLRP3 inflammasome inhibitors reported to be useful for the treatment of sepsis, stroke, atherosclerosis, gout, Alzheimer's disease, Parkinson’s disease, type I diabetes and cancer, among others.
Matchpoint Therapeutics Inc. and Novartis AG have entered into an exclusive option and license agreement to develop and commercialize oral covalent inhibitors targeting a transcription factor linked to a number of inflammatory diseases. Matchpoint’s approach leverages the properties of covalent chemistry and a proprietary platform to target a novel binding site on a historically hard-to-drug protein.
Serine/threonine-protein kinase NEK7 inhibitors are described in a recent Beijing Primegene Therapeutics Co. Ltd. patent. They are reported to be useful for the treatment of gout, osteoarthritis, amyotrophic lateral sclerosis, multiple sclerosis, ulcerative colitis, Alzheimer’s, Parkinson’s disease and cancer.
DCB-USA LLC and the Development Center for Biotechnology have patented heterocycle compounds acting as fMet-Leu-Phe receptor (fMLP; FPR1) antagonists reported to be useful for the treatment of cancer, acute respiratory distress syndrome, asthma, arthritis, chronic obstructive pulmonary disease, lung injury, ischemia-reperfusion injury and septicemia.
Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by chronic inflammation and structural damage to the alveoli, with irreversible declined lung function. M1 pro-inflammatory macrophages mainly participate in airway inflammation and in tissue destruction, and are involved in COPD, but the mechanisms need to be elucidated.
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