Researchers from The Salk Institute have described a signaling pathway that sets off an unusual, autophagy-dependent cell death mechanism as a fail-safe for cells that have evaded senescence mechanisms. The scientists found a tumor suppression mechanism mediated by telomere signaling, which activated an innate immune response through mitochondrial and telomere complexes to eliminate cells with shortened telomeres.

Scripps Research Institute and Shangpharma Innovation have divulged cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors reported to be useful for the treatment of autoinflammatory interferonopathy, autoimmune and neurological disorders.

Maresin-2 (MaR2) is a bioactive lipid derived from omega-3 polyunsaturated fatty acid.

Researchers from Jouf University and affiliated organizations have reported the discovery of novel cyclooxygenase-2 (COX-2) inhibitors as potential nonacidic anti-inflammatory agents.

Philadelphia University (Jordan) has synthesized 2,4-disubstituted-thieno[2,3-d]pyrimidines acting as prostaglandin G/H synthase 2 (COX-2) inhibitors.

Prazer Therapeutics Inc. has identified mitogen-activated protein kinase 14 (MAPK14) inhibitors reported to be useful for the treatment of inflammatory disorders.

Novartis AG has patented sphingosine 1-phosphate S1P3 receptor antagonists reported to be useful for the treatment of lung inflammation.

Researchers from Wenzhou Medical University and affiliated organizations have reported the discovery and preclinical evaluation of novel anti-inflammatory compounds. Synthesis and optimization of a new series of 1-(4-(benzylsulfonyl)-2-nitrophenyl) derivatives resulted in the identification of compound [I] as the lead candidate.