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BioWorld - Thursday, March 23, 2023
Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Representative images of MMP-12 stained (magenta) human kidney biopsies.
Nephrology

T cells initiate kidney inflammation in glomerulonephritis

March 22, 2023
By Mar de Miguel
No Comments
A study from the University Medical Center Hamburg-Eppendorf (UKE) in Germany has identified a type of T cell that triggered glomerulonephritis (GN) and produced loss of kidney function in mice. The scientists described an autoimmune pathway of this disease mediated by the accumulation of T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) in the kidneys and found a possible therapeutic target.
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Foot pain

Gout doubts Dissolve with dual phase III outcomes from Selecta, Sobi

March 21, 2023
By Randy Osborne
No Comments
Selecta Biosciences Inc. and Swedish Orphan Biovitrum AB unveiled top-line phase III data from the Dissolve I and II trials testing SEL-212 in adults with chronic refractory gout (CRG) – results that position the companies for a regulatory filing in the U.S. during the first half of next year. SEL-212 could take on Horizon Therapeutics plc’s Krystexxa (pegloticase), a pegylated uric acid specific enzyme cleared by the U.S. FDA for CRG in September 2010.
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Inflammatory

Reistone Biopharma divulges new MK2 inhibitors

March 20, 2023
No Comments
Reistone Biopharma Co. Ltd. has synthesized quinolinofuran derivatives acting as MAP kinase-activated protein kinase 2 (MAPKAPK2; MK2) inhibitors reported to be useful for the treatment of fibrosis, autoimmune, inflammatory and metabolic disorders.
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Inflammatory

Redx Pharma divulges DDR1 and DDR2 inhibitors

March 15, 2023
No Comments
Redx Pharma plc has described henyl- and pyridopyrazole derivatives as discoidin domain-containing receptor DDR1 and/or DDR2 inhibitors. They are reported to be useful for the treatment of fibrosis, cancer, transplant rejection, inflammatory, renal, liver and cardiovascular disorders.
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Respiratory

Tetra Bio-Pharma's oral ARDS-003 cleared by Health Canada to enter clinic

March 13, 2023
No Comments
Tetra Bio-Pharma Inc. has received clearance from Health Canada to proceed with a first-in-human trial in Canada using oral ARDS-003 (onternabez) to treat various immunomodulatory conditions. Oral ARDS-003 is positioned to modulate acute systemic inflammation and prevent sepsis, acute respiratory distress syndrome (ARDS) and organ damage.
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Lungs
Inflammatory

Discovery of novel anti-inflammatory agents with efficacy in models of acute lung injury and sepsis

March 10, 2023
No Comments
Researchers from Wenzhou Medical University and affiliated organizations presented the discovery of novel anti-inflammatory agents. Synthesis and optimization of a series of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives led to the identification of compound [I] as the lead, as it exhibited the best inhibitory effect in vitro. More specifically, [I] demonstrated the strongest inhibitory effect on LPS-induced TNF-α (82.58%) and IL-6 (75.05%) expression, while exhibiting no cytotoxicity at 10 μM in J774A.1 macrophages.
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Concept art for Mitochondrial DNA.
Inflammatory

Fumarate accumulation moderates inflammation through mitochondrial genetic material

March 10, 2023
By Mar de Miguel
No Comments
A deficiency in fumarate metabolism could be behind a new mechanism of inflammation mediated by mitochondrial DNA and RNA. Two independent and simultaneous studies described how the accumulation of fumarate in the mitochondria released the genetic material of this organelle through vesicles, activating an inflammatory signaling pathway.
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Infection

Autoantibodies against chemokines are possible ally against long COVID

March 7, 2023
By Mar de Miguel
No Comments
Autoantibodies are typically not good news. But a group of researchers from Bellinzona, Switzerland, have observed that the presence of autoantibodies against chemokines, a special class of cytokines, is associated with mild disease and less risk of developing long COVID. “Our hypothesis was that antibodies to chemokines, if they existed, would also be associated with a negative outcome of the disease. But, what we found, in fact, was the exact opposite of what we were predicting,” Davide Robbiani, director of the Institute for Research in Biomedicine, told BioWorld.
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Illustration of intestines with inflammation
Gastrointestinal

NP-011 shows antifibrotic effects in IBD mouse models

March 3, 2023
No Comments
Inflammatory bowel disease (IBD) is a complex and chronic inflammatory disorder of the...
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Gastrointestinal

Eosinophilic gastroenteritis murine model shows dependence on ILC2/IL-25 axis

March 2, 2023
No Comments
The pathogenesis of eosinophilic gastroenteritis (EGE), a chronic inflammatory disease characterized by eosinophil infiltration in the gastrointestinal tract, is still not well understood.
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