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BioWorld - Wednesday, March 3, 2021
Home » Topics » Neurology/Psychiatric, BioWorld

Neurology/Psychiatric, BioWorld
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Neurocrine schizophrenia thesis intact post-Interact? Opinions differ on phase II data

March 2, 2021
By Randy Osborne
No Comments
San Diego-based Neurocrine Biosciences Inc.’s good-and-bad top-line phase II data with d-amino acid oxidase inhibitor luvadaxistat, also known NBI-1065844 and TAK-831, in schizophrenia likely came as little surprise to many, given earlier experience in the general pathway.
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Financial chart, upward arrow

Vaccinex shares vroom higher on mystery discovery deals

Feb. 19, 2021
By Michael Fitzhugh
No Comments
News of Vaccinex Inc. signing two multitarget deals with undisclosed "prominent pharmaceutical companies" sent company shares (NASDAQ:VCNX) up 70% to $4.88 on Feb. 19, even as financial terms of the deal went undisclosed. The collaborations will focus on using the company's ActivMAb antibody discovery and novel viral display platform to develop candidates against complex antigens such as G protein-coupled receptors and ion channels, the company said.
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FDA sign

Cortexyme Alzheimer’s study placed on partial clinical hold

Feb. 16, 2021
By Lee Landenberger
No Comments
The FDA placed a partial clinical hold on atuzaginstat (COR-388) from Cortexyme Inc., of South San Francisco, stating that no new participants should be enrolled in the open-label extension portion of the phase II/III GAIN trial in mild to moderate Alzheimer’s disease.
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Psychiatric disorders illustration

Research making strides even as mystery abounds in schizophrenia

Feb. 12, 2021
By Randy Osborne
No Comments
Recently published findings in JAMA Psychiatry related to the sharply increased risk of death from COVID-19 in people with schizophrenia put the spotlight on drug development in the space, which has been steadily heating up the past few years.
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Gold dollar sign

Pipeline Therapeutics closes $80M crossover round as data readouts loom

Feb. 11, 2021
By Cormac Sheridan
No Comments
As it waits on initial data from its two lead programs, in sensorineural hearing loss and multiple sclerosis, Pipeline Therapeutics Inc. raised $80 million in a series C crossover round to progress its pipeline of small-molecule drugs for neuroregeneration and to position it for a potential IPO.
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Mesoblast phase III chronic back pain trial meets pain reduction endpoint, reduces opioid use

Feb. 11, 2021
By Tamra Sami
No Comments
PERTH, Australia – After hitting a few setbacks in recent months, regenerative medicine company Mesoblast Ltd. believes it finally has a path to market with its allogeneic mesenchymal precursor cell therapy, rexlemestrocel-L, in chronic low back pain.
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Tau neuron illustration

Alzheimer's vaccine advances with positive interim data

Feb. 11, 2021
By Michael Fitzhugh
No Comments
Nearly five months after its tau-directed antibody, semorinemab, failed to demonstrate efficacy in a phase II trial in Alzheimer’s disease, AC Immune SA is back with positive data on a different approach with its anti-phospho-tau vaccine candidate, ACI-35.030.
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Cannabidiol

Jazz proves its chops; harmonic rhythm with GW in $7.2B deal

Feb. 3, 2021
By Randy Osborne
No Comments
Questions about the price tag, the extent of diligence done on intellectual property, and the staying power of Epidiolex (cannabidiol) as well as the potential of other prospects in the acquiree’s pipeline bubbled up during the conference call related to Jazz Pharmaceuticals plc’s whopping takeover of GW Pharmaceuticals plc.
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Seniors with wooden puzzle

Cassava’s simufilam improves AD patients’ cognition, behavior

Feb. 2, 2021
By Lee Landenberger
No Comments
When Cassava Sciences Inc.’s president and CEO, Remi Barbier, opened up the interim analysis of the company’s open-label study for Alzheimer’s disease candidate simufilam, he was more than pleased with the results but found himself an audience of one. His researchers had been confident about the results before the data were tallied. “I was ecstatic,” he told Bioworld. “No one’s seen this type of improvement in Alzheimer’s. But our scientists said, ‘See, I told you so.’ It was not my expectation.” The new data showed six months’ treatment with the oral, small molecule not just stabilized but improved cognition and behavior scores in AD patients.
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Alopecia program takes center stage at Concert after schizophrenia failure

Feb. 1, 2021
By Jennifer Boggs
No Comments
Concert Pharmaceuticals Inc. is scratching further work on CTP-692 after the deuterated form of D-serine missed the primary endpoint in a phase II study in schizophrenia. The news sent shares of Concert (NASDAQ:CNCE) falling 28% Feb. 1 and shifts focus to the firm’s sole remaining clinical-stage program in the competitive alopecia areata space.
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