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BioWorld - Monday, May 19, 2025
Home » Topics » Disease categories and therapies » Neurology/psychiatric

Neurology/psychiatric
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Neurology/psychiatric

Neushen Therapeutics discovers new NLRP3 inflammasome inhibitors

April 22, 2025
Neushen Therapeutics Inc. has described NLRP3 inflammasome inhibitors reported to be useful for the treatment of autoimmune disease, cardiovascular disorders, neurodegeneration and chronic obstructive pulmonary disease.
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Neurology/psychiatric

Bexson and Saint Joseph’s University divulge new NMDA receptor antagonists

April 22, 2025
Researchers at Bexson Biomedical Inc. and Saint Joseph’s University have synthesized NMDA receptor antagonists reported to be useful for the treatment of neurological and psychiatric disorders.
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Brain illustration
Neurology/psychiatric

First-in-class, oral small-molecule SERCA inhibitor for synucleinopathies

April 22, 2025
Researchers from Aarhus University and Synuca Therapeutics recently presented a novel drug-like small-molecule inhibitor of sarco/endoplasmic reticulum calcium ATPase (SERCA), SYN-4569, with superior pharmacological properties and evaluated its efficacy in vitro and in vivo. SYN-4569 is an orally available compound with good potency, pharmacokinetics and brain-penetrant properties.
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Neurology/psychiatric

FDA grants orphan drug designation to BA-102 for Phelan-McDermid syndrome

April 22, 2025
Neuronos Ltd., a subsidiary of Beyond Air Inc., has announced BA-102 has been awarded U.S. orphan drug designation for the treatment of Phelan-McDermid syndrome.
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Illustration of cell dividing
Cancer

Germline variants’ impact on pan-cancer proteome

April 22, 2025
By Mar de Miguel
A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations. The results provide a broad view of cancer risk that could be useful for patient stratification and the design of prevention strategies.
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Neurology/psychiatric

Suzhou Vigonvita Life Sciences patents new 5-HT1A receptor agonists

April 17, 2025
Suzhou Vigonvita Life Sciences Co. Ltd. has disclosed 5-HT1A receptor agonists reported to be useful for the treatment of neurological disorders.
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Illustration representing connection between brain and gut microbiome.
Neurology/psychiatric

CJRB-302 restores gut microbiota, improves motor symptoms, and prevents neurodegeneration in PD

April 17, 2025
At the 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD), researchers from Rutgers University investigated the therapeutic potential of CJRB-302, a live biotherapeutic product derived from healthy human gut microbiota, to improve PD motor symptoms and pathology.
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Man piecing together a puzzle
Neurology/psychiatric

Discovery and preclinical results of a Rac1 inhibitor for Alzheimer’s

April 17, 2025
At the 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD), researchers from Beijing Joekai Biotechnology LLC presented the discovery process and preclinical results for 50561.
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Illustration of neurons with Lewy bodies
Neurology/psychiatric

Parkinson’s vaccine selectively targets pathogenic αSyn

April 17, 2025
At the 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD), Promis Neurosciences Inc. presented its new approach to optimizing the α-synuclein (α-Syn) vaccine composition in order to maximize targeting of toxic α-Syn species.
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Neurology/psychiatric

Alzheimer’s vaccine selectively targets toxic amyloid-β oligomers

April 17, 2025
Promis Neurosciences Inc. recently presented the rational design of an Alzheimer’s disease (AD) vaccine candidate maximizing the selective targeting of toxic amyloid-β oligomers.
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