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BioWorld - Thursday, September 28, 2023
Home » Topics » Disease categories and therapies » Neurology/Psychiatric

Neurology/Psychiatric
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Mindrhythm's headset

Headset could improve safety of return-to-play decisions after concussion

Aug. 23, 2023
By Meg Bryant
No Comments
For many sports injuries, return-to-play decisions are pretty straightforward: pain and swelling have dissipated, or an X-ray confirms that a bone has healed. For concussion, it’s not so clear. Though symptoms may resolve after a few days, the brain could still be vulnerable. Now, Cupertino, Calif.-based based startup Mindrhythm Inc. has developed a headset to assess concussion recovery using biometric measures and help doctors safely return concussed individuals to play.
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Neurology/Psychiatric

Chengdu Kanghong Pharmaceutical patents new Nav1.8 blockers

Aug. 23, 2023
No Comments
Chengdu Kanghong Pharmaceutical Co. Ltd. has disclosed sodium channel protein type 10 subunit alpha (Nav1.8) channel blockers reported to be...
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Illustration demonstrating muscle contraction in amyotrophic lateral sclerosis.
Neurology/Psychiatric

Akava announces IND clearance for AKV-9 to enter clinic for ALS

Aug. 23, 2023
No Comments
Akava Therapeutics Inc. has announced FDA clearance of its IND application for AKV-9 (formerly NU-9) for the treatment of amyotrophic lateral sclerosis (ALS). The company is planning a first-in-human phase I study in healthy subjects.
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Brain and encephalography
Neurology/Psychiatric

NS-041, a novel KCNQ2/3 activator for the treatment of epilepsy, presented at ACS meeting

Aug. 23, 2023
No Comments
Voltage-gated potassium channels (KCNQ) control neural excitability and their dysfunction leads to neuronal channelopathies frequently related to...
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Stem cells
Neurology/Psychiatric

Stem cell study functionally links Alzheimer’s risk genes

Aug. 23, 2023
By Anette Breindl
No Comments
Investigators have functionally linked the Alzheimer’s disease (AD) risk gene SORL1 to apolipoprotein E (ApoE) and clusterin, another apolipoprotein. The work, Tracy Young-Pearse told BioWorld, is part of an attempt to “try to understand different subtypes of Alzheimer’s disease.” It maps some of what Young-Pearse termed the “many molecular roads that lead to Alzheimer’s” – which, in turn, is the first step to setting up roadblocks. Young-Pearse is an associate professor in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital and Harvard Medical School and co-leader of the Harvard Stem Cell Institute’s Nervous System Diseases Program. She is also the senior author of the paper describing the findings, which appeared online in Cell Reports on Aug. 22, 2023.
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Incannex to begin pivotal trials in US for synthetic cannabinoid for sleep apnea

Aug. 22, 2023
By Tamra Sami
No Comments
Incannex Healthcare Ltd. is gearing up to begin a pivotal phase II/III trial in the U.S. for its lead asset, IHL-42X (dronabinol/acetazolamide), a synthetic cannabinoid combination drug for sleep apnea.
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Digital brain and silhouette

Brainaurora files for Hong Kong IPO to develop digital therapeutics

Aug. 22, 2023
By Doris Yu
No Comments
Brainaurora Medical Technology Ltd. has filed for an initial public offering (IPO) in Hong Kong to develop its digital therapeutics for the treatment of cognitive impairment diseases. The company claims to be the first in China to launch a digital therapeutics (DTx) product for cognitive impairment, as well as the largest company in China in terms of revenue from the commercialization of cognitive impairment DTx products in 2022.
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SPR Therapeutic Inc.’s Sprint PNS system

More than 20,000 patients have found relief with Sprint PNS system

Aug. 22, 2023
By Annette Boyle
No Comments
Over the last six years, more than 20,000 patients have been implanted with the Sprint PNS system to manage acute or chronic pain, SPR Therapeutics Inc. reported. The 20,000th patient was treated for low back and leg pain with the Sprint Extensa XT system, which like the company’s other systems is implanted for 60 days in a minimally invasive surgery. The system uses percutaneous peripheral nerve stimulation (PNS) to recondition the central nervous system to provide long-term, significant relief from pain.
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Neurocrine’s Ingrezza gets expanded FDA nod in chorea associated with HD

Aug. 21, 2023
By Jennifer Boggs
No Comments
The impact of a black box warning on Neurocrine Biosciences Inc.’s expanded U.S. label for Ingrezza (valbenazine) to treat chorea associated with Huntington’s disease (HD) appears up for debate, following FDA approval late Aug. 18. But analysts agree that it is unlikely to affect sales of the VMAT2 inhibitor in tardive dyskinesia, for which the company recently raised 2023 guidance as high as $1.82 billion.
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AI-generated art of brain connections

Brain maps uncover individual differences in psychiatric disorders

Aug. 21, 2023
By Mar de Miguel
No Comments
The study of six types of mental illnesses in a thousand brain regions has demonstrated the differences between individuals within each disorder. Using magnetic resonance images (MRI), scientists from Monash University in Australia analyzed the brain changes and built individual maps for each psychiatric disorder. Their results revealed differences between people with the same diagnosis, which could help refine assessments.
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