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BioWorld - Saturday, May 16, 2026
Home » Topics » Disease categories and therapies » Neurology/psychiatric

Neurology/psychiatric
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Neurology/psychiatric

Centessa’s OX2R agonist ORX-142 gains IND clearance

June 17, 2025
No Comments
Centessa Pharmaceuticals plc has obtained IND clearance from the FDA to initiate a phase I study of ORX-142 in healthy volunteers. ORX-142 is an investigational, novel, highly potent and selective OX2R agonist being developed for the treatment of select neurological and neurodegenerative disorders.
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Reset Moves action shot

Reset Moves to promote well-being in children with neurodivergence

June 16, 2025
By Tamra Sami
Focused on promoting well-being amongst children with neurodivergence, Reset Moves Pty Ltd. created app-based games to help children not only focus with greater clarity, but also to better help them re-engage in certain settings.
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For $795M, Sage is added to Supernus’ CNS quiver

June 16, 2025
By Lee Landenberger
No Comments
Supernus Pharmaceuticals Inc. is buying Sage Therapeutics Inc. for about $795 million. The deal brings Supernus, already firmly in the CNS market, the only U.S. FDA-approved oral treatment for postpartum depression. Supernus CEO Jack Khattar said he believes sales will support the acquisition, but some analysts had their doubts.
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Neurology/psychiatric

Nanjing Mingde New Drug Research discovers new KCNQ2/3 activators

June 16, 2025
Nanjing Mingde New Drug Research Co. Ltd. has described potassium voltage-gated channel subfamily KQT member 2/3 (KCNQ2/3) activators reported to be useful for the treatment of epilepsy.
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Brain with puzzle piece removed
Index insights

Safety scares and trial misses drag down neuro biotechs into Q2

June 13, 2025
By Amanda Lanier
No Comments
The BioWorld Neurological Diseases Index continued its downward slide into 2025, with 15 of the 20 component stocks posting losses. After dipping into negative territory in late February, the index dropped 15.99% by the end of March and closed May down 22.34%.
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Neurology/psychiatric

Startup Elkedonia raises €11M to advance neuroplastogen in depression

June 13, 2025
By Nuala Moran
No Comments
Newco Elkedonia SAS has raised €11 million (US$12.7 million) in a seed round, which will fund it to take a potentially first-in-class ELK-1 inhibitor into the clinic in the treatment of refractory depression. ELK-1 plays a pivotal role in neuroplasticity and in reward circuits in the brain, which when disrupted can lead to depression, addiction and post-traumatic stress disorder.
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Two silhouettes with tangle, gear, spiral
Newco news

Startup Elkedonia raises €11M to advance neuroplastogen in depression

June 12, 2025
By Nuala Moran
No Comments
Newco Elkedonia SAS has raised €11 million (US$12.7 million) in a seed round, which will fund it to take a potentially first-in-class ELK-1 inhibitor into the clinic in the treatment of refractory depression. ELK-1 plays a pivotal role in neuroplasticity and in reward circuits in the brain, which when disrupted can lead to depression, addiction and post-traumatic stress disorder.
Read More
Neurology/psychiatric

Maplight Therapeutics patents new GPR52 modulators

June 12, 2025
Maplight Therapeutics Inc. has disclosed G protein-coupled receptor GPR52 modulators reported to be useful for the treatment of neurological and psychiatric disorders.
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Steadying hand while reaching for glass
Neurology/psychiatric

Capsida’s CAP-003 receives IND clearance for Parkinson’s disease with GBA mutations

June 12, 2025
No Comments
Capsida Biotherapeutics Inc. has obtained IND clearance from the FDA for CAP-003, an intravenously administered gene therapy, for Parkinson’s disease associated with GBA mutations (PD-GBA). A phase I/II trial will begin dosing in the third quarter of this year.
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Neurology/psychiatric

Tetrahydropyridine-4-azaindole derivatives to quiet sodium channels in epilepsy

June 12, 2025
No Comments
Epilepsy affects more than 70 million worldwide and while several drugs have proven effective for controlling seizures, around 30% of patients do not respond to them and their side effects can be intolerable.
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