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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
Respiratory RSS Feed RSS

Roches Cobas system and test

Roche launches breakthrough 12-target PCR test

Oct. 3, 2024
By Shani Alexander
Roche AG’s new test using its temperature-activated generation of signal technology is the next step in PCR evolution, Igor Kozlov, head of Reagent Research and Design at Roche Diagnostics Solutions, told BioWorld. The Cobas Respiratory flex test can detect up to 12 of the most common respiratory viruses using a single PCR test.
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mRNA on digital background
Respiratory

Inhaled mRNA-based therapy rescues CFTR function

Oct. 3, 2024
The development of cystic fibrosis transmembrane conductance regulator (CFTR) modulators has significantly improved the therapeutic scenario for CF patients in the past decade. However, around 10% of patients harboring nonsense and splice-site mutations are nonresponsive to CFTR modulators.
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Lungs
Respiratory

Preclinical profiling of Splisense’s inhaled antisense oligonucleotide

Oct. 3, 2024
Researchers from Splisense Ltd. and affiliated organizations recently reported preclinical data for SPL-84, an inhaled antisense oligonucleotide drug candidate being developed for the treatment of patients with cystic fibrosis carrying the 3849 +10 kb C-to-T (3849) mutation.
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Lungs
Respiratory

4D-710 gene therapy helps overcome lack of response to CFTR modulators

Oct. 2, 2024
Scientists from 4D Molecular Therapeutics Inc. disclosed the preclinical evaluation of 4D-710, an aerosolized gene therapy that consists of a lung-specific evolved A101 capsid vector, the promoter CMV173 and the transgene codon-optimized human CFTRΔR.
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DNA illustration
Immune

Prime Medicine outlines plans for gene editing pipeline

Oct. 1, 2024
Prime Medicine Inc. has announced its plans to strategically focus its efforts on a set of high value programs as it advances its pipeline of next-generation gene editing therapies.
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Heart and lungs

Cereno's CS1 passes phase IIa pulmonary arterial hypertension trial

Sep. 30, 2024
By Randy Osborne
Cereno Scientific AB’s positive top-line results from the phase IIa trial of histone deacetylase inhibitor CS1 in pulmonary arterial hypertension provide a “clear path forward” in the debilitating, fatal disease, the company said.
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Regeneron sends up a flare in COPD with Dupixent FDA nod

Sep. 27, 2024
By Randy Osborne
The U.S. FDA’s approval of yet another indication for Dupixent (dupilumab), partnered between Regeneron Pharmaceuticals Inc. and Sanofi SA, could mean another $6.4 billion-plus in sales by the end of the decade. Regulators cleared the drug as an add-on maintenance treatment for chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype who are prone to flare-ups. Dupixent, the first-ever biologic for COPD, entered the market in March 2017.
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Handshake with tech background
Respiratory

Generate:Biomedicines signs up Novartis to $1B+ multitarget deal

Sep. 27, 2024
By Brian Orelli
Novartis AG is enlisting the help of Generate:Biomedicines Inc. and its artificial intelligence platform to generate drugs for multiple undisclosed targets. The number of targets and therapeutic areas also weren’t disclosed. Novartis will pick the targets, although the targets Generate has been working on are off limits. Generate will be responsible for creating the lead candidate, at which point Novartis will take over development.
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Hands holding torn contract

Masimo: Kiani out, Brennan in as CEO following investor vote

Sep. 25, 2024
By Annette Boyle
Joe Kiani’s reign at Masimo Corp. abruptly ended following a vote at the annual shareholders meeting on Sept. 19 that saw Kiani, Masimo’s founder and CEO, ousted from the board as part of a hard-fought battle with activist investor Politan Capital Management. Michelle Brennan, a Politan nominee and former Johnson & Johnson senior executive who won her board seat last year, was named interim CEO.
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Handshake with tech background

Generate:Biomedicines signs up Novartis to $1B+ multitarget deal

Sep. 24, 2024
By Brian Orelli
Novartis AG is enlisting the help of Generate:Biomedicines Inc. and its artificial intelligence platform to generate drugs for multiple undisclosed targets. The number of targets and therapeutic areas also weren’t disclosed. Novartis will pick the targets, although the targets Generate has been working on are off limits. Generate will be responsible for creating the lead candidate, at which point Novartis will take over development.
Read More
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