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BioWorld - Thursday, June 5, 2025
Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

Teva begins IND-enabling studies with BD-9

May 28, 2025
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Teva Pharmaceutical Industries Ltd. has commenced IND-enabling studies with BD-9, a dual-specific multibody targeting thymic stromal lymphopoietin (TSLP) and interleukin-13 (IL-13). By simultaneously blocking two key drivers of TH2-driven inflammation, BD-9 has the potential to improve outcomes for patients with conditions such as atopic dermatitis and asthma.
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Respiratory

An anti-inflammatory α-diazoester to treat acute lung injury

May 27, 2025
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Activation of the α7 nicotinic acetylcholine receptor may be therapeutically useful against acute lung injury by suppressing expression of pro-inflammatory genes.
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Lungs
Respiratory

SR-1375 shows promise for treating pneumonia with comorbidities

May 27, 2025
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Aging and chronic conditions are risk factors for mortality in patients with pneumonia. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a recognized biomarker of vascular inflammation, where high levels of Lp-PLA2 have been found in the plasma of patients with several chronic conditions such as chronic kidney disease or diabetes.


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Respiratory

Enanta Pharmaceuticals discovers new 17β-HSD13 inhibitors

May 26, 2025
Enanta Pharmaceuticals Inc. has described 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of liver (hepatocellular carcinoma) cancer, cirrhosis, idiopathic pulmonary fibrosis and nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH).
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Lungs and bronchiole
Biomarkers

NEIL2 downregulation worsens COPD symptoms, study finds

May 26, 2025
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Researchers from the U.S. have published findings regarding the link between low NEIL2 expression and airway inflammation and increased DNA damage.
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Lungs
Respiratory

IBI-3002 exerts potent anti-inflammatory activity in preclinical asthma models

May 23, 2025
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Interleukin-4 receptor α (IL-4Rα), a shared receptor subunit for both IL-4 and IL-13, along with thymic stromal lymphopoietin (TSLP), are key drivers of the type 2 inflammatory cascade involved in asthma and other inflammatory disorders.
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Respiratory

New antagonists of cannabinoid CB1 receptor to alleviate allergic rhinitis

May 23, 2025
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Nearly half of the world’s population suffers from allergic rhinitis, meaning that when they inhale allergens from the air, IgE becomes activated and induces paroxysmal sneezing, runny nose and nasal itching. Several types of drugs are currently used to manage the condition, including antihistamines, corticosteroids and antagonists of the leukotriene receptor; but some are associated with side effects.
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Respiratory

New Nav1.7 channel blockers for cough disclosed in Chiesi patent

May 22, 2025
Chiesi Farmaceutici SpA has divulged sodium channel protein type 9 subunit α (Nav1.7) channel blockers reported to be useful for the treatment of chronic cough.
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Lungs
Respiratory

PERK inhibition reverses asbestos-induced pulmonary fibrosis in mice

May 22, 2025
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Pulmonary fibrosis is a lung disease with limited therapeutic options and the development of new therapeutics is a clinical unmet need. Little is known about the role of endoplasmic reticulum stress and unfolded protein response seen in macrophages during pulmonary fibrosis.
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Lungs
Respiratory

Astrazeneca’s AZD-6793 arises as a promising therapeutic for COPD

May 22, 2025
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Chronic obstructive pulmonary disease (COPD) is among the most leading causes of death around the world and there are insufficient treatment options that prevent exacerbations or alter the progression of the disease. COPD is a complex disease with multiple factors driving inflammation, emphysema or small airway remodeling, among others, where interleukin-1 receptor-associated kinase 4 (IRAK-4) plays a crucial role in the pathogenesis of the disease.
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