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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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Respiratory

Haisco Pharmaceutical identifies new LPAR1 antagonists

March 25, 2025
Haisco Pharmaceutical Group Co. Ltd. has described lysophosphatidic acid receptor 1 (LPAR1; EDG2) antagonists reported to be useful for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis, benign prostate hyperplasia, multiple sclerosis, neuronal injury and neuralgia.
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Respiratory

Roche discloses new NLRP3 inflammasome inhibitors

March 25, 2025
Scientists from F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented NLRP3 inflammasome and interleukin-1β (IL1B; IL-1β) release inhibitors reported to be useful for the treatment of asthma, chronic obstructive pulmonary disease, Alzheimer’s and Parkinson’s diseases.
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Immune

MTH1 inhibition for treating allergic airway inflammation

March 25, 2025
Asthma affects about 300 million people worldwide. Inflammation in asthma may drive irreversible airway remodeling due to subepithelial fibrosis, extracellular matrix degradation and increased smooth muscle cell mass levels, among others. In vitro and in vivo assays were performed to test MutT homolog 1 (MTH1) as a therapeutic target in allergic airway inflammation.
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Lungs anatomy
Respiratory

Efficient TGF-β mRNA delivery to mouse lung parenchyma via ionizable amphiphilic Janus dendrimers

March 21, 2025
Several lung conditions, such as acute lung injury, require the targeted delivery of pharmacological agents to the lower lung. However, the administration of complex biologics, such as anti-inflammatory cytokine mRNA, to the injury site in the lower lungs is particularly challenging, frequently leading to poor specificity and uneven distribution.
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Brainomix 360 Stroke platform

Brainomix raises £14M for AI-powered imaging solution for stroke, lung fibrosis

March 20, 2025
By Shani Alexander
Brainomix Ltd. raised £14 million ($18 million) in a series C financing round to expand its AI-powered imaging solution, Brainomix 360 Stroke, into the U.S. market. Funds will also go towards advancing the Brainomix 360 E-Lung, which can accurately predict the progression of lung fibrosis. “This series C round is a vital fundraise for us,” Michalis Papadakis, CEO and co-founder of Brainomix, told BioWorld. “We are in a growth stage where we want to bring this next generation of stroke AI into the U.S. market.”
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Lungs
Respiratory

LMO7 as therapeutic target to block profibrotic fibroblast polarization in IPF

March 19, 2025
Researchers from Shanghai Jiao Tong University and affiliated organizations have published their findings from studies that aimed to investigate the pathogenesis of idiopathic pulmonary fibrosis (IPF) and identify novel regulators of the disease.
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Illustration of alveoli and lungs
Respiratory

Smsbiotech’s small mobile stem cell therapy cleared to enter clinic for COPD

March 19, 2025

Smsbiotech Inc. has gained clearance in Australia to begin a phase I trial of its small mobile stem (SMS) cell therapy for chronic obstructive pulmonary disease (COPD). 


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Insilico Medicine CEO Alex Zhavoronkov with Insilico’s first bipedal humanoid AI Scientist called “Supervisor.”

Insilico advancing AI platform with $110M Asian-backed series E round

March 18, 2025
By Tamra Sami
Artificial intelligence (AI) drug developer Insilico Medicine raised $110 million in a series E round led by an Asian private equity fund, Value Partners Group, that will see Insilico advance its pipeline and AI platform developments.
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Coronavirus, lungs

Healios posts more upbeat data on Multistem cell therapy for ARDS

March 18, 2025
By Marian (YoonJee) Chu
Latest findings on Healios K.K.’s stem cell therapy to treat acute respiratory distress syndrome (ARDS), coined Multistem (invimestrocel; HLCM-051), found the regenerative medicine effective in reducing the number of patient days on ventilator treatment, as well as mortality benefits.
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China accepts NDA of influenza tablet, clears Tepezza biosimilar

March 18, 2025
By Marian (YoonJee) Chu
China’s National Medical Products Administration (NMPA) approved the country’s first injectable teprotumumab biosimilar from Innovent Biologics Inc. under the brand name of Sycume (teprotumumab N-01) to treat thyroid eye disease on March 14. The NMPA on March 15 accepted Simcere Pharmaceutical Group Ltd.’s NDA of deunoxavir marboxil (ADC-189) tablets, a product originally developed by Jiaxing Andicon Biotech Co. Ltd. to treat influenza A and B.
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