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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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AI-generated image of illustration of MRI of lungs with fibrosis
Respiratory

Adenine base editing corrects G542X mutation in CFTR in patient organoid models

March 13, 2025
Cystic fibrosis (CF) is a life-threatening autosomal recessive disease affecting over 160,000 people worldwide. CF is caused by loss-of-function mutations in the CF transmembrane conductance regulator (CFTR) that mediates Cl and HCO3 anion transport.
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Lungs wireframe illustration
Respiratory

OC-STAMP identified as a potential diagnostic biomarker and therapeutic target for silicosis

March 13, 2025
Silicosis, resulting from prolonged exposure to free crystalline silica dust, is an occupational disease characterized by silica nodules and extensive lung tissue fibrosis. The etiology of silicosis remains unclear, challenging early detection and effective treatment.
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Mesothelioma

Keeping a bead on TEAD in mesothelioma, Vivace raises $35M more

March 12, 2025
By Randy Osborne
Vivace Therapeutics Inc. closed a $35 million series D round led by RA Capital Management, an existing investor, and including other backers already on board: Canaan Partners and Cenova Capital. Proceeds will support the continued development of what the company describes as its first-in-class and best-in-class transcriptional enhanced associate domain autopalmitoylation (TEAD) inhibitor, VT-3989, with an initial focus on mesothelioma.
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Genome concept art.
Infection

Study looks to noncoding gene variants for new drug targets

March 12, 2025
By Nuala Moran
A new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on gene expression levels and gene splicing, the post-transcriptional modification that allows one gene to code for multiple proteins.
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Leyden Labs raises $70M for intranasal flu drugs, acquires Covbio

March 11, 2025
By Marian (YoonJee) Chu
Leyden Laboratories BV added a fresh $70 million in financing to advance Panflu, its phase II-ready intranasal pan-influenza prophylactic medicine, while acquiring Cov Biotechnology Pte. Ltd. (Covbio) and its zoonotic virus-targeting portfolio to prepare for the next pandemic.
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Alex Zhavoronkov, founder and CEO, Insilico Medicine

AI drug developer Insilico sees advantages to China market

March 11, 2025
By Tamra Sami
Insilico Medicine founder and CEO Alex Zhavoronkov told BioWorld that he tries to spend as much time as possible in China, because that's where the artificial intelligence (AI) drug development company conducts synthesis and tests for early stage discovery. “And nowadays, not a day goes by without somebody launching an AI drug discovery company,” he said, noting that Chinese AI company Deepseek could be a huge disrupter.
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Gavel and scales

Clinical trial fraud ends with guilty pleas

March 11, 2025
By Mari Serebrov
In another real-life episode of “sponsor beware,” the owners of a clinical research facility pleaded guilty March 10 in U.S. district court to fraud charges resulting from their conduct of two clinical trials for potential asthma drugs.
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Stethoscope, hand, health care icons

CDC briefing: Trump cuts disrupt disease surveillance, deplete talent

March 10, 2025
By Nuala Moran
Three public health experts have voiced concerns that the uncertainties sparked by the Trump administration’s moves to reduce federal spending could limit the U.S. CDC’s ability to track and respond to infectious disease outbreaks and will undermine the public health support system in the U.S.
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Alex Zhavoronkov, founder and CEO, Insilico Medicine

AI drug developer Insilico sees advantages to China market

March 6, 2025
By Tamra Sami
Insilico Medicine founder and CEO Alex Zhavoronkov told BioWorld that he tries to spend as much time as possible in China, because that's where the artificial intelligence (AI) drug development company conducts synthesis and tests for early stage discovery. “And nowadays, not a day goes by without somebody launching an AI drug discovery company,” he said, noting that Chinese AI company Deepseek could be a huge disrupter.
Read More
Genome concept art.

Study looks to noncoding gene variants for new drug targets

March 6, 2025
By Nuala Moran
A new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on gene expression levels and gene splicing, the post-transcriptional modification that allows one gene to code for multiple proteins.
Read More
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