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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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Respiratory

MyD88 inhibitor with improved drug-like properties, anti-inflammatory activity

Jan. 23, 2025
Researchers from Wenzhou Medical University and affiliated organizations presented the discovery and preclinical characterization of a novel myeloid differentiation primary response 88 (MyD88) inhibitor for the treatment of acute lung injury (ALI).
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Masimo headquarters

Masimo names med-tech vet Katie Szyman CEO

Jan. 22, 2025
By Annette Boyle
Masimo Corp. selected Catherine (Katie) Szyman, an industry leader with deep med-tech roots, to guide the company as it seeks to rebuild its reputation and revenues following a gritty two-year battle for control. Current CEO Michelle Brennan will serve as chairman of the Masimo board. Brennan stepped up to lead Masimo after founder and former CEO Joe Kiani resigned following a shareholder vote that ousted him from his position of board chair as part of a protracted proxy battle between Kiani and Politan Capital Management LP.
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White strand of DNA
Biomarkers

Wnt/PCP signaling mediators identified as new markers in yellow nail syndrome

Jan. 20, 2025
Researchers from Tel Aviv Sourasky Medical Center presented data from a study that aimed to investigate the genetic mechanisms underlying yellow nail syndrome (YNS), a rare disorder characterized by three features, namely yellow dystrophic nails, lymphedema and chronic lung disease.
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Twindemic diagnostic

Incheon team mints new diagnostic test tailored to ‘twindemics’

Jan. 16, 2025
By Marian (YoonJee) Chu
Researchers have developed a novel point of care (POC) diagnostic that can test for multiple respiratory viral infections simultaneously, including for the flu and COVID-19. The POC diagnostic tool leverages a novel, non-enzymatic signal amplification method, according to study lead Eunjung Kim, professor at Incheon National University (INU), whose team published the findings in Sensors and Actuators B: Chemical online November 2024.
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Cardiovascular illustration
Cardiovascular

Novel PDE5 inhibitor for pulmonary arterial hypertension identified

Jan. 16, 2025
Phosphodiesterase 5 (PDE5) is a cGMP-specific hydrolytic enzyme highly expressed in pulmonary vascular smooth muscle cells.
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Yuhan, Oscotec stock gains as J&J hits ‘gold standard’ in NSCLC

Jan. 14, 2025
By Marian (YoonJee) Chu
Yuhan Corp., Oscotec Inc. and Genosco Inc. were three companies with Asian ties to reap benefit from Johnson & Johnson’s stellar top-line Mariposa study results, wherein J&J’s Rybrevant (amivantamab-vmjw) and Lazcluze (lazertinib) combo regimen beat out Astrazeneca plc’s standard of care in non-small-cell lung cancer (NSCLC).
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Scanning electron micrograph of M. tuberculosis
Respiratory

In monkeys, enhanced TB vaccine dissolves after inducing protection

Jan. 14, 2025
By Mar de Miguel
An experimental tuberculosis (TB) vaccine with a dual mission – self-destruction after inducing immunity – improved the design of the Bacillus Calmette-Guérin (BCG) immunotherapy, a vaccine also used against cancer. Scientists at the University of Pittsburgh engineered this strain with a double break, which is effective and safer after an intravenous administration, according to their results in nonhuman primates and mice.
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Inflammatory

Gilead and Leo Pharma partner on oral STAT6 program

Jan. 13, 2025
Gilead Sciences Inc. and Leo Pharma A/S have established a strategic partnership to accelerate the development and commercialization of Leo’s small-molecule oral STAT6 programs for the treatment of inflammatory diseases.
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Windward Bio launches with an in-licensed asset for asthma and COPD

Jan. 10, 2025
By Brian Orelli
Windward Bio AG was established with plans to both license a drug and establish wet labs to create an internal pipeline of drug candidates. SR One, Omega Funds, RTW Investments, Qiming Venture Partners, Quan Capital and Pivotal Bioventure Partners funded the Basel, Switzerland-based company’s $200 million series A financing round.
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Yuhan, Oscotec stock gains as J&J hits ‘gold standard’ in NSCLC

Jan. 8, 2025
By Marian (YoonJee) Chu
Yuhan Corp., Oscotec Inc. and Genosco Inc. were three companies with Asian ties to reap benefit from Johnson & Johnson’s stellar top-line Mariposa study results, wherein J&J’s Rybrevant (amivantamab-vmjw) and Lazcluze (lazertinib) combo regimen beat out Astrazeneca plc’s standard of care in non-small-cell lung cancer (NSCLC).
Read More
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