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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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AI generated illustration of lungs in the human body
res

RUNX2-regulated LEPR+ fibroblasts significantly contribute to pathological fibroblasts in fibrosis

Feb. 21, 2025
Researchers from Columbia University Irving Medical Center and collaborators applied unbiased scRNA-seq to study Lepr expression in lung mesenchymal cells. To do that, they used a Lepr(creERT2) mouse model tracing LEPR+ alveolar fibroblasts during neonatal alveologenesis.
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Close up of man wearing nebulizer

Trial begins for inhaled gene therapy for cystic fibrosis

Feb. 20, 2025
By Nuala Moran
The longstanding ambition of developing an inhaled gene therapy for cystic fibrosis has taken a step forward, with the start of a phase I/II trial of a product using a novel pseudotyped viral vector that it is hoped will circumvent problems encountered in previous studies with other vectors.
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Small extracellular vesicle
Cancer

Clots and metastasis in cancer patients start in the lung

Feb. 20, 2025
By Mar de Miguel
The lung and thrombosis may play a key role in cancer and metastasis progression, according to a collaborative study led by Cornell University scientists. In the nonmetastatic lung microenvironment of several cancer types, the development of a prothrombosis niche promotes metastasis formation through the release of small extracellular vesicles loaded with an integrin protein.
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Novel coronavirus SARS-CoV-2
Infection

KVX-053 alleviates acute lung injury in COVID-19

Feb. 19, 2025
Researchers from Kevirx Inc. and collaborators have described the use of KVX-053, a PTP4A3 inhibitor aimed to be used for the prevention of COVID-19-associated cute lung injury (ALI).
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Respiratory

G-protein coupled receptor kinase is cystic fibrosis target

Feb. 19, 2025
Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to misfold and be prematurely degraded. Despite approved drugs that restore the CFTR protein, the maximal lung function improvement is approximately 14%.
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Lab glassware and antibodies art concept
Inflammatory

Series A financing at Bambusa to advance bispecific antibodies for immunological and inflammatory disorders

Feb. 17, 2025
Bambusa Therapeutics Inc. has completed an oversubscribed series A financing of approximately $90 million to support its lead programs through phase I trials and advance its pipeline of long-acting bispecific antibodies for immunological and inflammatory disorders.
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Illustration of antibodies binding to human cell receptors
Respiratory

Akeso’s IL-4Rα/ST2 bispecific antibody gains IND clearance in China

Feb. 14, 2025
Akeso Inc. has received IND approval by China’s National Medical Products Administration (NMPA) for AK-139, an IL-4Rα/ST2 bispecific antibody under investigation for a number of indications, including respiratory and skin diseases.
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Antibody-drug conjugate

Ligachem gets rights to Daan’s antibody for solid tumor ADCs

Feb. 13, 2025
By Marian (YoonJee) Chu
Ligachem Biosciences Inc. landed another exclusive licensing deal to develop and commercialize antibody-drug conjugates (ADCs), this time with T-cell receptor therapy specialist Daan Biotherapeutics Inc. for a cancer-targeting antibody.
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Uncharted territory’ for Pliant after IPF trial pause

Feb. 13, 2025
By Jennifer Boggs
Pliant Therapeutics Inc., which offered few details earlier this week when it voluntarily paused enrollment in the phase IIb Beacon-IPF trial testing bexotegrast in idiopathic pulmonary fibrosis (IPF), has taken an unusual step as it assembles a panel of outside experts to review unblinded data from the study with the goal of providing an independent recommendation.
Read More
Antibody-drug conjugate

Ligachem gets rights to Daan’s antibody for solid tumor ADCs

Feb. 13, 2025
By Marian (YoonJee) Chu
Ligachem Biosciences Inc. landed another exclusive licensing deal to develop and commercialize antibody-drug conjugates (ADCs), this time with T-cell receptor therapy specialist Daan Biotherapeutics Inc. for a cancer-targeting antibody.
Read More
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