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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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Respiratory

KT-621: a first-in-class STAT6 degrader for Th2-driven diseases

May 22, 2025
No Comments
STAT6 plays a central role in regulating Th2-driven immune responses. Recent studies have identified gain-of-function mutations in the STAT6 gene that are associated with early-onset, severe allergic diseases. As a result, STAT6 has emerged as a promising therapeutic target in conditions such as asthma, eosinophilic inflammation, food allergies and atopic dermatitis, particularly in cases that are refractory to standard therapies.
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Respiratory

Zymeworks’ bispecific antibody relieves airway inflammation in asthma and COPD models

May 21, 2025
No Comments
Chronic obstructive pulmonary disease (COPD) is a prevalent and heterogeneous respiratory disorder with limited effective treatments. IL-33 and IL-4Rα are key mediators of airway inflammation in COPD and hence represent potential therapeutic targets.
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Lung illustration

Galvanize’s Aliya could enable one-step tumor biopsy and ablation

May 20, 2025
By Annette Boyle
Galvanize Therapeutics Inc.’s Aliya pulsed electrical field system could enable surgeons to perform a biopsy and ablate lung tumors at the same time, a study in the Journal of Surgical Oncology indicates.
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3d rendering of bispecific antibodies

Pfizer bets $6B+ on 3Sbio’s bispecific PD-1/VEGF antibody

May 20, 2025
By Marian (YoonJee) Chu
No Comments
Pfizer Inc. is paying $1.25 billion up front and up to $4.8 billion in milestone payments to gain global, ex-China rights to SSGJ-707, a PD-1/VEGF bispecific antibody from 3Sbio Inc. that recently won China clearance for a phase III study in lung cancer as a potential first-line monotherapy. Announced after U.S. market hours May 19, the exclusive agreement for SSGJ-707 spells up to $6.15 billion combined for Shenyang, China-based 3Sbio, along with separate tiered double-digit royalty payments on sales of SSGJ-707, if approved.
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AI-generated image of illustration of MRI of lungs with fibrosis
Respiratory

Atyr begins IND-enabling studies with candidate for pulmonary fibrosis

May 15, 2025
No Comments
Atyr Pharma Inc. has advanced ATYR-0101 into IND-enabling studies for pulmonary fibrosis, and is targeting an IND application in the second half of next year.
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Digital lungs illustration
Respiratory

Next-generation inhibitor of the P2Y14 receptor to treat acute lung injury

May 14, 2025
No Comments
The metabotropic nucleotide receptor P2Y14 shows strong potential as a therapeutic target against various inflammatory diseases, particularly acute lung injury, yet the small-molecule inhibitors described so far have performed poorly in preclinical studies.
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Lung illustration
Respiratory

BLR Bio’s BLR-200 demonstrates antifibrotic effects in lung fibrosis model

May 2, 2025
No Comments
BLR Bio LLC has announced new data on BLR-200, its lead compound for systemic sclerosis and lung fibrosis. In the new study, BLR-200 demonstrated the ability to reduce key disease tissue markers for fibrotic lung disease.
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Gastrointestinal

Equillium advancing new AhR modulator

May 2, 2025
No Comments
Equillium Inc. is advancing EQ-504, a potent aryl hydrocarbon receptor (AhR) modulator acquired through the acquisition of Ariagen Inc., a company that was majority owned by Equillium’s largest investor, Decheng Capital.
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Illustration of cell dividing
Cancer

Germline variants’ impact on pan-cancer proteome

April 25, 2025
By Mar de Miguel
A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations.
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World map with supply chain icons

Free trade zones not a simple workaround for tariffs

April 23, 2025
By Mari Serebrov
If U.S. sectoral tariffs on biopharmaceuticals become a reality and most country-by-country tariffs on other medical products resume, manufacturers may have to rethink their use of U.S. free trade zones to turn foreign-sourced active pharmaceutical ingredients and other components into finished products for the U.S. market.
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