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Home » Topics » Disease categories and therapies » Respiratory

Respiratory
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World map with supply chain icons

Free trade zones not a simple workaround for tariffs

April 23, 2025
By Mari Serebrov
If U.S. sectoral tariffs on biopharmaceuticals become a reality and most country-by-country tariffs on other medical products resume, manufacturers may have to rethink their use of U.S. free trade zones to turn foreign-sourced active pharmaceutical ingredients and other components into finished products for the U.S. market.
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Lungs
Respiratory

MARCKS protein is potential target in equine asthma model

April 23, 2025
A recent study in Respiratory Research further investigated the expression and role of the myristoylated alanine-rich C kinase substrate (MARCKS) protein in a horse model of asthma.
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Inflammatory

Aclaris gains IND clearance for bispecific anti-TSLP/IL-4R antibody

April 23, 2025
Aclaris Therapeutics Inc. has gained IND clearance from the FDA for ATI-052, a bispecific anti-thymic stromal lymphopoietin (TSLP)/interleukin-4 receptor (IL-4R) monoclonal antibody being developed to treat certain immuno-inflammatory diseases. A phase Ia/Ib trial, including a proof-of-concept portion in an undisclosed indication, will begin in the current quarter.
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Illustration of cell dividing
Cancer

Germline variants’ impact on pan-cancer proteome

April 22, 2025
By Mar de Miguel
A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations. The results provide a broad view of cancer risk that could be useful for patient stratification and the design of prevention strategies.
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Respiratory

New cathepsin C inhibitors disclosed in Insmed patent

April 16, 2025
Insmed Inc. has divulged cathepsin C (dipeptidyl peptidase I, DPP1) inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis, asthma, metastatic cancer, chronic rhinosinusitis, heart failure, inflammatory bowel disease, psoriasis and thrombosis, among others.
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Sanofi advances asthma drug despite phase II miss

April 15, 2025
By Lee Landenberger
Despite missing a phase II study’s primary endpoint in moderate to severe asthma, Sanofi SA sees a way forward to a phase III program in the crowded disease space. Preliminary results showed the annualized exacerbation rate endpoint wasn’t met at the highest dosage of amlitelimab. Those numbers, at week 48, showed nominal significance at the medium dose.
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Viruses

Pandemic potential is plentiful, but the next bug’s specifics are known unknown

April 15, 2025
By Anette Breindl
Compared to other forms of prevention, a unique issue for pandemic preparedness is that it is forever unclear what pathogen, exactly, the world needs to be prepared for. There are an estimated 300,000 viruses that infect mammals; add in birds, and the estimate grows to more than half a million. Some of those viruses are much greater threats than others.
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Antibodies binding to spike proteins on the surface of SARS-CoV-2 virus
Inflammatory

Australian researchers discover new compound to treat long COVID

April 15, 2025
By Tamra Sami
Researchers have developed a new compound that can prevent long COVID symptoms in mice that could lead to a future drug for the debilitating condition in humans. Developed by researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, the world-first study found mice treated with the antiviral compound were protected from long-term brain and lung dysfunction, which are key symptoms of long COVID.
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Respiratory

Shanghai Yidi Biotechnology patents new ELANE inhibitors

April 11, 2025
Shanghai Yidi Biotechnology Co. Ltd. has disclosed neutrophil elastase (ELANE; leukocyte elastase) inhibitors reported to be useful for the treatment of pain and respiratory tract inflammation.
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Woman scanning test tubes in the lab

MDCG downgrades risk classification for COVID-19 tests

April 9, 2025
By Mark McCarty
The EU’s Medical Devices Coordination Group (MDCG) issued another revision of its guidance for risk classification for in vitro diagnostics — the fourth such rewrite of a guidance that came out in 2020.
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