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Home » Topics » Drugs » Antibiotic

Antibiotic
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Summit’s phase III failure slices the stock nearly in half

Dec. 20, 2021
By Lee Landenberger
Antibiotics continue to take a beating as top-line results from Summit Therapeutics Inc.’s phase III study of ridinilazole failed to meet the primary endpoint for sustained clinical response and treating C. difficile infection (CDI). Looking for an upside on its lead candidate’s results, the company noted participants treated with ridinilazole had substantially less recurrence of CDI, the most common cause of diarrhea in hospitalized patients, as compared to those who were administered vancomycin (nominal p-value = 0.0002).
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Capsules in blister packs

Better incentives needed to tackle antibiotic resistance

Nov. 22, 2021
By Mari Serebrov
Even as antimicrobial resistance is expected to continue to grow, the development of much-needed novel antibiotics and antifungals remains trapped in a catch-22 in which funding is available for early stage research but not necessarily for the translational work necessary to bring the drugs to market.
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Petri dish and capsules
Newco news

Micreos sidesteps antibiotic resistance, targeting superbugs with $37M for endolysin

Oct. 4, 2021
By Richard Staines
Developing the next generation of antibiotics is proving to be a major problem, with research reaching an almost standstill due to a lack of funding because of the poor return on R&D investment from the products.
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Back pain

Persica primes trial for new approach to lower back pain

Aug. 19, 2021
By Nuala Moran
LONDON – Persica Ltd. is poised to take a new pharmaceutical approach to curing chronic lower back pain, after delivering positive data in a phase Ib study of an injectable antibiotic. The development rests on research showing that, as with stomach ulcers, chronic lower back pain is caused by localized bacterial infection.
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U.K. study identifies another danger of COVID-19: increased antibiotic resistance

June 2, 2021
By Nuala Moran
LONDON – Adding to the immediate and obvious toll of serious illness and death, COVID-19 seems likely to be fueling development of resistance to antibiotic drugs, according to the findings of the most comprehensive analysis to date.
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The next phage in combating antimicrobial resistance

Feb. 24, 2021
By Peter Winter
With the clock ticking on the urgent need to develop new antibiotics, the ongoing COVID-19 pandemic has given policy makers a sharp reminder that society should not lose focus on antibiotic resistance as well, which has the potential to dwarf COVID-19 in terms of deaths and economic costs. The Centers for Disease Control and Prevention, for example, noted in its Antibiotic Resistance Threats in the U.S. 2019 report that more than 2.8 million antibiotic-resistant infections occur each year, and more than 35,000 people die as a result. Against a universal decline in the effectiveness of antibiotics, there has been a renaissance of interest in using phage therapy, whose use has waxed and waned for almost a century.
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Petri dishes
BIF 2020

No time to lose to curb rising tide of antimicrobial resistance

Oct. 16, 2020
By Peter Winter
In July a major initiative of the International Federation of Pharmaceutical Manufacturers and Associations, designed to combat the rising tide of antimicrobial resistance and accelerate the pace at which new antibiotics are discovered and brought to market, was announced. The $1 billion AMR Action Fund, supported by 23 pharma companies, was created “because there was a clear realization that we have no time to spare to address the lack of innovation in this area,” said Martin Bott, interim general manager of the fund, who described the progress being made with the fund in a fireside chat at this week’s virtual BIO Investor Forum.
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Petri dish

Australia’s Recce raises AU$28 million to advance new class of synthetic anti-infectives

Sep. 29, 2020
By Tamra Sami
PERTH, Australia – Sydney-based Recce Pharmaceuticals Ltd. completed a placement of AU$27.95 million (US$19.69 million) to advance its synthetic anti-infective pipeline.
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Petri dish

Australia’s Recce raises AU$28 million to advance new class of synthetic anti-infectives

Sep. 25, 2020
By Tamra Sami
PERTH, Australia – Sydney-based Recce Pharmaceuticals Ltd. completed a placement of AU$27.95 million (US$19.69 million) to advance its synthetic anti-infective pipeline to address antibiotic-resistant superbugs and emerging viral pathogens.
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Petri dish and capsules

Singapore-based researchers find a SMART way to reduce bacterial antibiotic resistance

Aug. 25, 2020
By David Ho
HONG KONG – Researchers from the Massachusetts Institute of Technology’s (MIT) research enterprise in Singapore have found a way to not just reverse antibiotic resistance but also increase sensitivity in some bacteria, using hydrogen sulfide.
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