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Home » Topics » Drugs » Antibiotic

Antibiotic
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Infection

Improved LpxC inhibitor antibiotic ready for human trials

Aug. 10, 2023
By Mar de Miguel
A different class of antibiotics could ease the increasing resistance triggered by some gram-negative bacteria. LpxC inhibitors are not new, but all attempts to develop them have failed due to cardiovascular toxicity or ineffectiveness. A modification of the structure of these compounds may have solved the problem. Duke University scientists demonstrated the preclinical safety and efficacy of an LpxC inhibitor candidate against a wide selection of these pathogens.
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Drug Design, Drug Delivery & Technologies

Synthetic antibiotics pack multiple punches against gram-positive bacteria

July 13, 2023
By Mar de Miguel
A chance discovery has led to a new class of antibiotics with multiple arms that interacted with the cell wall of gram-positive bacteria, inhibiting their assembly and disarming them. “It was an accidental discovery. We were using it to stain cells. We also were running evaluations of antibiotics. One of my former students came to me and said: ‘I think we have discovered something that is quite potent as an antibiotic,’” the senior author Xingyu Jiang told BioWorld.
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Xacduro

Entasis’ bacterial infection drug receives FDA approval

May 24, 2023
By Lee Landenberger
A week ahead of its May 29 PDUFA date, the U.S. FDA has approved Xacduro (sulbactam for injection; durlobactam for injection) for treating one of the toughest and most deadly infections, carbapenem-resistant Acinetobacter baumannii, in adults.
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Colorized scanning electron micrograph of MRSA.
Infection

For fighting staph infections, multitasking fusion protein is perfect 10

April 26, 2023
By Coia Dulsat
Researchers at NYU Langone Health and Janssen Biotech Inc. have reported on mAbtyrins, bioengineered molecules composed of human monoclonal antibodies and centyrins that are a new way to fight Staphylococcus aureus infection on all fronts.In their experiments, which were published in Cell Host & Microbe on April 24, 2023, the team described mAbtyrin, as “a protein-based therapeutic that targets 10 disease-causing mechanisms employed by S. aureus,” senior author Victor Torres told BioWorld.
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Petri dish and capsules

Debate heating up over EU voucher proposal for tackling AMR

Feb. 17, 2023
By Nuala Moran
The stage is set for a showdown between the pharma industry and national governments and public health experts over which policy the EU should grasp, as it bids to create a pan-European incentive scheme that will encourage innovation and get more antibiotics through to market. At issue is a proposal supported by the industry, under which companies getting approval for a new antibiotic would be given a voucher allowing them to extend market exclusivity of any different drug of their choice for one year.
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GSK forges on with antibiotic R&D as gepotidacin hits targets in phase III

Nov. 3, 2022
By Richard Staines
GSK plc has announced it has stopped early two pivotal phase III trials of its urinary tract infection drug, gepotidacin, for efficacy and is preparing regulatory filings for what could be the first new oral antibiotic for the disease in more than 20 years.
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Antibiotics development incentive scheme makes economic sense, EFPIA says

Sep. 28, 2022
By Mari Serebrov
To jumpstart the development of much-needed antibiotics, the European Federation of Pharmaceutical Industries and Associations (EFPIA) released a new report Sept. 28 demonstrating the economic benefit of granting additional exclusivity for another drug as a way of incentivizing antibiotic R&D.
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Dollar signs in blister packs

Spero signs $600M license deal for UTI antibiotic with GSK – three months after FDA rejected it

Sep. 22, 2022
By Richard Staines
Spero Therapeutics Inc. has come out swinging after a U.S. FDA rejection for its oral antibiotic, tebipenem Hbr, picking up a potential $600 million licensing deal with pharma giant GSK plc after agreeing on a plan with the regulator to revive the drug.
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Women handshake with virology graphics

BI, Evotec and Biomérieux go where big pharma fears to tread, forming antibiotic research JV

July 6, 2022
By Richard Staines
Hot on the heels of a groundbreaking deal brokered by the U.K.’s NICE to finance an antibiotic with a subscription-style payment plan, three European life sciences companies have formed a joint venture (JV) to create next-generation antimicrobials and diagnostics to fight antimicrobial resistance.
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US FDA rejects Spero’s oral antibiotic tebipenem, demanding further trial

June 28, 2022
By Richard Staines

Spero Therapeutics Inc.’s oral antibiotic, tebipenem Hbr, has been rejected by the U.S. FDA for adults with complicated urinary tract infection, after the regulator said a further trial is needed for approval.


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