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Home » Topics » Drugs » RNAi

RNAi
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Prostate cancer cells
Cancer

Inhibiting miR-1271-5p reduces growth of hormone sensitive prostate cancer cell lines

Sep. 18, 2024
Researchers from Imperial College London presented data from a study that aimed to assess the role of miR-1271-5p in prostate cancer (PCa) progression.
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Liver illustration
Endocrine/metabolic

JNJ-75220795 demonstrates rapid systemic absorption and elimination

Sep. 13, 2024
Researchers from Janssen Research & Development LLC presented preclinical data for JNJ-75220795 (ARO-PNPLA3), a GalNAc-conjugated small interfering RNA (siRNA) therapeutic targeting the PNPLA3 gene, being developed for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).
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3D illustration of RNA
Endocrine/metabolic

Haya, Lilly target metabolic disorders with $1B lncRNA pact

Sep. 5, 2024
By Nuala Moran
The dark matter of long non-coding RNA (lncRNA) is shades brighter, after the signing of two major deals between biotech pioneers and big pharma in the past week. Haya Therapeutics SA announced Sept. 4 that it has sealed a multiyear agreement with Eli Lilly and Co. to apply its lncRNA platform technology to identify targets in obesity and related metabolic disorders.
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3D illustration of RNA

Haya, Lilly target metabolic disorders with $1B lncRNA pact

Sep. 4, 2024
By Nuala Moran
The dark matter of long non-coding RNA (lncRNA) is shades brighter, after the signing of two major deals between biotech pioneers and big pharma in the past week. Haya Therapeutics SA announced Sept. 4 that it has sealed a multiyear agreement with Eli Lilly and Co. to apply its lncRNA platform technology to identify targets in obesity and related metabolic disorders.
Read More
Pancreas illustration

Arrowhead chases Ionis in rare, genetic disease race

Sep. 3, 2024
By Lee Landenberger
With a successful phase III study of plozasiran in hand, Arrowhead Pharmaceuticals Inc. plans to file an NDA with the U.S. FDA for treating the rare genetic disease familial chylomicronemia syndrome. While the data are strong, the company is playing catch-up to Ionis Pharmaceuticals Inc., which has a December 2024 PDUFA for its candidate, olezarsen, in the same indication.
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Learning curve: Alnylam vutrisiran phase III sparks data debates

Aug. 30, 2024
By Randy Osborne

Potential implications for others in the space, including Pfizer Inc. and Bridgebio Pharma Inc., became the subject of buzz after Alnylam Pharmaceuticals Inc. provided details from the Helios-B phase III study with RNAi candidate vutrisiran, in the works for ATTR amyloidosis with cardiomyopathy.


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Hand adjusting gears
Newco news

Borealis from Novartis is born from the remains of Chinook

Aug. 22, 2024
By Lee Landenberger
There was more juice to be extracted from the grape that was the very successful Chinook Therapeutics Inc., so two investors have decided to make the most of it. Novartis AG and Versant Ventures have launched Borealis Biosciences Inc. from Chinook’s remnants to develop RNA therapies for treating kidney disease.
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Feet on scale
Endocrine/metabolic

Arrowhead takes aim at obesity

Aug. 16, 2024
Arrowhead Pharmaceuticals Inc. announced its plans to advance its RNAi drug candidates ARO-INHBE and ARO-ALK7 into clinical trials for the treatment of obesity and metabolic diseases.
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RNA strand

Biontech, Triastek ink $1.2B deal to 3D print oral RNA therapies

July 30, 2024
By Marian (YoonJee) Chu
Triastek Inc., of Nanjing, China, scored a potential $1.2 billion collaboration and platform technology license deal with Biontech SE to manufacture oral RNA therapeutics with 3D printing technology.
Read More
RNA strand

Biontech, Triastek ink $1.2B deal to 3D print oral RNA therapies

July 25, 2024
By Marian (YoonJee) Chu
Triastek Inc., of Nanjing, China, scored a potential $1.2 billion collaboration and platform technology license deal with Biontech SE to manufacture oral RNA therapeutics with 3D printing technology.
Read More
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