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Home » Topics » Drugs » RNAi

RNAi
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RNA strand

Biontech, Triastek ink $1.2B deal to 3D print oral RNA therapies

July 24, 2024
By Marian (YoonJee) Chu
Triastek Inc., of Nanjing, China, scored a potential $1.2 billion collaboration and platform technology license deal with Biontech SE to manufacture oral RNA therapeutics with 3D printing technology.
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Single strand RNA

BIX Korea 2024: Promise of mRNA technology for cell and gene therapy

July 16, 2024
By Marian (YoonJee) Chu
The industry is looking, with renewed hope, to the “promise” of messenger RNA (mRNA) therapeutics for a wide range of diseases beyond COVID-19, and not only in vaccine form but also for gene and cell therapies.
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Single strand RNA

BIX Korea 2024: Promise of mRNA technology for cell and gene therapy

July 10, 2024
By Marian (YoonJee) Chu
The industry is looking, with renewed hope, to the “promise” of messenger RNA (mRNA) therapeutics for a wide range of diseases beyond COVID-19, and not only in vaccine form but also for gene and cell therapies.
Read More
Liver illustration
Endocrine/metabolic

Liver-targeted siRNA improves body composition in mouse models

July 8, 2024
Large-scale human genetic studies have revealed that loss-of-function INHBE variants are associated with a lower abdominal to gluteofemoral fat ratio, improved metabolic profile, and reduced fasting glucose levels.
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Théa ends deal with Olix, returns rights of ocular drugs

June 25, 2024
By Marian (YoonJee) Chu
France’s Théa Open Innovation, a subsidiary of Laboratoires Théa SAS, terminated its licensing agreement with South Korea’s Olix Pharmaceuticals Inc., and returned global rights of Olix’s ocular small interfering RNA (siRNA) biologic agents, OLX-301D and OLX-301A.
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Théa ends deal with Olix, returns rights of ocular drugs

June 24, 2024
By Marian (YoonJee) Chu
France’s Théa Open Innovation, a subsidiary of Laboratoires Théa SAS, terminated its licensing agreement with South Korea’s Olix Pharmaceuticals Inc., and returned global rights of Olix’s ocular small interfering RNA (siRNA) biologic agents, OLX-301D and OLX-301A.
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‘Big win’ as Alnylam’s vutrisiran succeeds in rare heart disease

June 24, 2024
By Jennifer Boggs
Any skepticism that might have been lingering in the wake of Alnylam Pharmaceuticals Inc.’s February decision to tweak the analysis plan for the Helios-B trial testing vutrisiran in transthyretin amyloidosis with cardiomyopathy appeared to dissipate as the company reported top-line data showing the study met the primary and all secondary endpoints.
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Person holding weight with assistance

Avidity shares rise on FSHD data, plans for registrational study

June 12, 2024
By Jennifer Boggs
Shares of Avidity Biosciences Inc. hit a 52-week high on reports of promising data from the first efficacy cohort of its phase I/II Fortitude study testing delpacibart braxlosiran (del-brax) in facioscapulohumeral muscular dystrophy (FSHD), including impressive biomarker results that could indicate a path for potential accelerated approval.
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MASH-up: Ochre joins a $1B+ deal with Boehringer as Hepion struggles

April 22, 2024
By Lee Landenberger
In a deal that could exceed $1 billion for Ochre Bio Ltd., the U.K.-based liver disease therapy developer will collaborate with Boehringer Ingelheim GmbH. In the meantime, Hepion Pharmaceuticals Inc. shut down its lead candidate’s phase IIb study while looking for a lifeline.
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DNA in drug capsules

GSK draws bead on NASH target as Arrowhead bows out: $1B deal

Nov. 23, 2021
By Randy Osborne
Glaxosmithkline plc (GSK) tapped Arrowhead Pharmaceuticals Inc. for its foray into nonalcoholic steatohepatitis (NASH), as the pair signed an exclusive global licensing deal (excluding China) for GSK to develop and commercialize phase I/II-stage ARO-HSD, Arrowhead’s RNAi therapy targeting HSD17B13.
Read More
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