Trefoil Therapeutics Inc.'s $28 million from an oversubscribed series A financing will let the company finish a phase IIa proof-of-concept study as researchers edge toward attacking corneal endothelial dystrophy, including Fuchs dystrophy, a disease that leads to the deterioration of the endothelial layer on the back surface of the cornea.

LONDON – AM-Pharma BV has raised €116 million (US$130.7 million) in a series E round to fund phase III development of its recombinant alkaline phosphatase, Recap, in the treatment of sepsis-associated acute kidney injury (SA-AKI).

Some new investors pitched in to Recursion Pharmaceuticals Inc.'s $121 million series C financing, adding to the industry's vision of the importance of AI and machine learning.

Valeo Pharma Inc., of Montreal, said it filed its final short form prospectus in each of the provinces and territories of Canada in connection with its sale of a minimum of 4 million units and a maximum of 16 million units at CA50 cents each for gross proceeds of between CA$2 million (US$1.53 million) and CA$8 million (US$6.13 million). 

Horizon Therapeutics plc, of Dublin, said Horizon Pharma U.S. Inc., its wholly owned subsidiary, priced its offering of $600 million aggregate principal amount of 5.5% senior notes due 2027. 

Although the public biopharmaceutical sector set a fast pace at the beginning of the year, it has been all downhill since February, with the BioWorld Biopharmaceutical index losing 16% of its value. However, a strong performance in June, with the group gaining 7.6%, helped the sector marginally push into positive territory year-to-date (YTD). At the halfway point of the year, the index is trailing the general market by a wide margin, with the Dow Jones Industrial Average trading up 14% and the Nasdaq Composite index up 20%. 

Phagomed Biopharma GmbH, a Viennese company born of frustrations with the rise of multidrug-resistant infections and confidence in the potential for bacteriophage therapies to address them, has landed a €1.5 million (US$1.7 million) equity investment from new and existing investors. It's the second part of a €2.3 million seed financing, raised ahead of a series A round the company hopes to secure in 2020 to help it move toward the clinic in 2021.

Hemostemix Inc., of Calgary, Alberta, said it will not proceed with its nonbrokered private placement of up to $6 million in secured convertible debentures and will not have a second close of its nonbrokered private placement of up to $1 million in secured convertible debentures, which previously raised gross proceeds of $525,000. The company said it continues to pursue efforts to raise capital to fund operations and an ongoing phase II trial.

Hummingbird Bioscience Pte. Ltd., of Singapore, said it completed an extended series A financing round led by Heritas Capital Management and SEEDS Capital, the investment arm of Enterprise Singapore.

DUBLIN – Early stage vaccine developer Osivax SAS raised €8 million (U$9 million) in series A funding to continue development of a clinical-stage universal influenza vaccine, based on what it believes is a highly immunogenic method of presenting the viral nucleoprotein to the immune system.